2-(2-溴乙基)-1,3-二氧杂环己烷合成路线 （共 18 条）
反应条件
hydrogen bromide 1 h; Ambient temperature;
参考文献
Sato, Toshio; Kawara, Tatsuo; Sakata, Kazumi; Fujisawa, Tamotsu
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 2 p. 505 - 508
反应条件
toluene-4-sulfonic acid in dichloromethane Ambient temperature; Yield given;
参考文献
Australian Journal of Chemistry, , vol. 41, # 6 p. 881 - 895
反应条件
tert.-butyl lithium 1) diethylether, -78 deg C, 5 min, r.t., 1h ; 2) -78 deg C; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 55, # 19 p. 5404 - 5406
反应条件
magnesium Yield given. Multistep reaction;
参考文献
Lee, Yuh-Shan; Valle ,Luis del; Larson, Gerald L.
Synthetic Communications, 1987 , vol. 17, # 4 p. 385 - 392
反应条件
copper(I) bromide dimethylsulfide complex; magnesium 1.) THF, rt, 1 h, 2.a) THF, Me2S, -78 deg C, 15 h, b) up to 0 deg C, 4 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Franck-Neumann; Miesch; Lacroix; Metz; Kern
Tetrahedron, 1992 , vol. 48, # 10 p. 1911 - 1926
反应条件
C54H80Cl2Fe2N2O4 in diethyl ether T=22°C; 0.5 h; Inert atmosphere;
参考文献
Qian, Xin; Dawe, Louise N.; Kozak, Christopher M.
Dalton Transactions, 2011 , vol. 40, # 4 p. 933 - 943
反应条件
in acetonitrile 48 h; Heating / reflux;
参考文献
Ortho-McNeil Pharmaceutical, Inc.
Patent: EP906091 B1, 2006 ;
Location in patent: Page/Page column 21 ;
反应条件
ammonium chloride; magnesium in tetrahydrofuran
参考文献
Matsumoto, Takahiro; Katayama, Nozomi; Mabuchi, Hiroshi
Patent: US2003/144338 A1, 2003 ;
反应条件
magnesium 1.) THF, 30 min, reflux; 2.) THF, 12 h, room temperature; Yield given. Multistep reaction;
参考文献
Laatsch, Hartmut; Pudleiner, Heinz
Liebigs Annalen der Chemie, 1989 , p. 863 - 882
反应条件
magnesium 1.) THF, 30 min, reflux; 2.) THF, 12 h, room temperature; Yield given. Multistep reaction;
参考文献
Laatsch, Hartmut; Pudleiner, Heinz
Liebigs Annalen der Chemie, 1989 , p. 863 - 882
