6-甲基-4-氧代-1,4-二氢吡啶-3-羧酸合成路线 （共 8 条）
反应条件
1: With ammonium hydroxide 2: With dimethyl amine in water T=20 - 50°C; 3: With hydrogenchloride T=20°C; Further stages.;
参考文献
Fish, Paul V.; Ryckmans, Thomas; Stobie, Alan; Wakenhut, Florian
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 6 p. 1795 - 1798
反应条件
1: 83 percent / Na / 3 h / 60 °C 2: 81 percent / KOAc, H2 / 10percent Pd/C / propan-2-ol / 48 h / 20 °C / 3000.2 Torr 3: conc. aq. HCl / 24 h / Heating View Scheme
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
1: 89 percent / POCl3 / 4 h / 140 °C 2: 83 percent / Na / 3 h / 60 °C 3: 81 percent / KOAc, H2 / 10percent Pd/C / propan-2-ol / 48 h / 20 °C / 3000.2 Torr 4: conc. aq. HCl / 24 h / Heating View Scheme
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
1: 81 percent / KOAc, H2 / 10percent Pd/C / propan-2-ol / 48 h / 20 °C / 3000.2 Torr 2: conc. aq. HCl / 24 h / Heating View Scheme
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
1: 74 percent / KOAc, H2 / 10percent Pd/C / propan-2-ol / 48 h / 20 °C / 3000.2 Torr 2: 83 percent / conc. aq. HCl / 24 h / Heating View Scheme
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
hydrogenchloride 24 h; Heating;
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
hydrogenchloride 24 h; Heating; Yield given;
参考文献
Mittelbach, Martin
Synthesis, 1988 , # 6 p. 479 - 480
反应条件
in N,N-dimethyl-formamide
T=55°C; 2.5 h;
参考文献
DeJohn; Domagala; Kaltenbronn; Krolls
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1295 - 1302
