1,2,3,4-四氢-7-甲氧基咔唑合成路线 （共 16 条）
反应条件
hydrogen; palladium on activated charcoal in methanol P=735.508 Torr; 0.75 h;
参考文献
Banwell, Martin G.; Kelly, Brian D.; Kokas, Okanya J.; Lupton, David W.
Organic Letters, 2003 , vol. 5, # 14 p. 2497 - 2500
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; P=760 Torr; 0.333333 h; Title compound not separated from byproducts;
参考文献
Scott, Tricia L.; Burke, Nicholas; Carrero-Martinez, Grissell; Soederberg, Bjoern C.G.
Tetrahedron, 2007 , vol. 63, # 5 p. 1183 - 1190
反应条件
1: 80 percent / Cu powder / Pd(dba)2 / dimethylsulfoxide / 1 h / 50 °C 2: 97 percent / H2 / 10 percent Pd/C / methanol / 0.75 h / 735.51 Torr View Scheme
参考文献
Banwell, Martin G.; Kelly, Brian D.; Kokas, Okanya J.; Lupton, David W.
Organic Letters, 2003 , vol. 5, # 14 p. 2497 - 2500
反应条件
sodium methylate; copper(l) iodide in N,N-dimethyl-formamide 6 h; Heating;
参考文献
Kirugawa, Yasuo; Miyake, Yuko; Kawase, Masami
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 5 p. 1231 - 1236
反应条件
sodium acetate; acetic acid 4 h;
参考文献
MERCK and CO., INC.
Patent: WO2006/44232 A1, 2006 ;
Location in patent: Page/Page column 14; 16 ;
WO 2006/044232 A1
反应条件
toluene-4-sulfonic acid in ethanol Fischer indole synthesis; 2 h; Heating;
参考文献
Johnson, Peter D.; Sohn, Jeong-Hun; Rawal, Viresh H.
Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7899 - 7902
反应条件
1: 83 percent / CuI; Cs2CO3; 1,10-phenanthroline / dimethylformamide / 80 °C 2: 43 percent / p-toluenesulfonic acid / ethanol / 2 h / Heating View Scheme
参考文献
Johnson, Peter D.; Sohn, Jeong-Hun; Rawal, Viresh H.
Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7899 - 7902
反应条件
1: 98 percent / Na2CO3 / diethyl ether / 24 h / Ambient temperature 2: 1.) MeLi, t-BuLi View Scheme
参考文献
Wender, Paul A.; White, Alan W.
Tetrahedron, 1983 , vol. 39, # 22 p. 3767 - 3776
反应条件
methyllithium; tert.-butyl lithium Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wender, Paul A.; White, Alan W.
Tetrahedron, 1983 , vol. 39, # 22 p. 3767 - 3776
反应条件
sodium hydroxide; water; acetone
参考文献
Cummins; Tomlinson
Journal of the Chemical Society, 1955 , p. 3475
