(3-甲氧基-2-甲基苯基)甲醇合成路线 （共 10 条）
反应条件
1: With lithium borohydride; chloro-trimethyl-silane in tetrahydrofuran T=20°C; 18.1667 h; 2: With methanol in tetrahydrofuran T=0°C;
参考文献
Wyeth
Patent: US2007/203116 A1, 2007 ;
Location in patent: Page/Page column 8 ;
US 20070203116 A1
反应条件
lithium aluminium tetrahydride in diethyl ether T=20°C; Reduction;
参考文献
Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav
Tetrahedron Letters, 2000 , vol. 41, # 11 p. 1741 - 1745
反应条件
1.1: 98 percent / H2 / Pd/C / ethanol / 20 °C 2.1: NaNO2; H2SO4 / H2O / 0 °C 2.2: 99 percent / aq. H2SO4 / Heating 3.1: 100 percent / hydrogen chloride / Heating 4.1: 72 percent / K2CO3 / acetone / Heating 5.1: 100 percent / LiAlH4 / diethyl ether / 20 °C View Scheme
参考文献
Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav
Tetrahedron Letters, 2000 , vol. 41, # 11 p. 1741 - 1745
反应条件
1: 72 percent / K2CO3 / acetone / Heating 2: 100 percent / LiAlH4 / diethyl ether / 20 °C View Scheme
参考文献
Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav
Tetrahedron Letters, 2000 , vol. 41, # 11 p. 1741 - 1745
反应条件
1: 100 percent / hydrogen chloride / Heating 2: 72 percent / K2CO3 / acetone / Heating 3: 100 percent / LiAlH4 / diethyl ether / 20 °C View Scheme
参考文献
Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav
Tetrahedron Letters, 2000 , vol. 41, # 11 p. 1741 - 1745
反应条件
1.1: NaNO2; H2SO4 / H2O / 0 °C 1.2: 99 percent / aq. H2SO4 / Heating 2.1: 100 percent / hydrogen chloride / Heating 3.1: 72 percent / K2CO3 / acetone / Heating 4.1: 100 percent / LiAlH4 / diethyl ether / 20 °C View Scheme
参考文献
Peixoto, Christophe; Laurin, Patrick; Klich, Michel; Dupuis-Hamelin, Claudine; Mauvais, Pascale; Lassaigne, Patrice; Bonnefoy, Alain; Musicki, Branislav
Tetrahedron Letters, 2000 , vol. 41, # 11 p. 1741 - 1745
反应条件
lithium aluminium tetrahydride
参考文献
Mukharji,P.C. et al.
Indian Journal of Chemistry, 1971 , vol. 9, p. 515 - 523
参考文献
Winthrop Chem. Co.
Patent: US2281956 , 1940 ;
反应条件
1: thionyl chloride / dichloromethane / Reflux
2: N,N-dimethyl-formamide / 20 °C
3: hydrogen; ammonia / Raney Ni / water; methanol / 5 h / 20 °C / 2585.81 Torr
4: water / 50 °C
5: water; hydrogen bromide / 100 °C
6: triethylamine / water; tetrahydrofuran / 20 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRENNEMAN, Jehrod Burnett; GINN, John; LOWE, Michael D.; SARKO, Christopher Ronald; TASBER, Edward S.; ZHANG, Zhonghua
Patent: US2014/73629 A1, 2014 ;
反应条件
pyridinium chlorochromate in dichloromethane
T=20°C; 3.5 h;
参考文献
Wyeth
Patent: US2007/203116 A1, 2007 ;
Location in patent: Page/Page column 8 ;
US 20070203116 A1
