2-(4-氯苯基)-4-甲基-1,3-噻唑-5-羧酸甲酯合成路线 (共 3 条)
反应条件
in ethanol 2 h; Inert atmosphereReflux;
参考文献
Li, Ze; Khaliq, Mansoora; Zhou, Zhigang; Post, Carol Beth; Kuhn, Richard J.; Cushman, Mark
Journal of Medicinal Chemistry, 2008 , vol. 51, # 15 p. 4660 - 4671
反应条件
lithium hydroxide; water in methanol; ethanol 1 h; RefluxInert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 15 p. 4660 - 4671
反应条件
1.1: sodium hydroxide / methanol; water / 2 h / Reflux; Inert atmosphere
1.2: pH 2 / Inert atmosphere
2.1: thionyl chloride / 2 h / Reflux; Inert atmosphere
View Scheme
参考文献
Mayhoub, Abdelrahman S.; Khaliq, Mansoora; Kuhn, Richard J.; Cushman, Mark
Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1704 - 1714