2-(Boc-氨基)-2-(2-萘)乙酸合成路线 （共 13 条）
反应条件
sodium hydroxide in tetrahydrofuran T=24°C; 4 h;
参考文献
Kukolja; Draheim; Pfeil; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1886 - 1896
反应条件
hydrogenchloride; sodium carbonate in water
参考文献
Glaxo Laboratories Limited
Patent: US4107431 A1, 1978 ;
反应条件
1: With potassium hydroxide in ethanol; water 18 h; 2: With potassium hydrogensulfate in water
参考文献
Baruah, Pranjal K.; Dinsmore, Jason; King, Amber M.; Salome, Christophe; De Ryck, Marc; Kaminski, Rafal; Provins, Laurent; Kohn, Harold
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 11 p. 3551 - 3564
反应条件
1: With cesium fluoride in N,N-dimethyl-formamide T=100°C; P=7500.75 Torr; 3 h; Autoclave; 2: With hydrogenchloride in diethyl ether; water; N,N-dimethyl-formamide T=0°C; pH=2; Inert atmosphere;
参考文献
Mita, Tsuyoshi; Sugawara, Masumi; Hasegawa, Hiroyuki; Sato, Yoshihiro
Journal of Organic Chemistry, 2012 , vol. 77, # 5 p. 2159 - 2168
反应条件
1: N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-C-naphthalen-2-yl-methylamine With TMS-SnBu3; cesium fluoride in N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere; 2: carbon dioxide in N,N-dimethyl-formamide T=100°C; P=7500.75 Torr; 3 h; Autoclave; 3: With hydrogenchloride in diethyl ether; water; N,N-dimethyl-formamide pH=2; Inert atmosphere;
参考文献
Mita, Tsuyoshi; Chen, Jianyang; Sugawara, Masumi; Sato, Yoshihiro
Angewandte Chemie - International Edition, 2011 , vol. 50, # 6 p. 1393 - 1396
反应条件
1: 22.1 g / ethanol; H2O / 20 h / 50 °C 2: 16 percent aq. NaOH / 2.5 h / Heating 3: 85 percent / 1 N sodium hydroxide / tetrahydrofuran / 4 h / 24 °C View Scheme
参考文献
Kukolja; Draheim; Pfeil; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1886 - 1896
反应条件
1: 16 percent aq. NaOH / 2.5 h / Heating 2: 85 percent / 1 N sodium hydroxide / tetrahydrofuran / 4 h / 24 °C View Scheme
参考文献
Kukolja; Draheim; Pfeil; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1886 - 1896
反应条件
1: formic acid; zinc / methanol; water / 20 h / 20 °C 2: dichloromethane / 0 - 20 °C 3: potassium hydroxide / ethanol; water / 18 h View Scheme
参考文献
Baruah, Pranjal K.; Dinsmore, Jason; King, Amber M.; Salome, Christophe; De Ryck, Marc; Kaminski, Rafal; Provins, Laurent; Kohn, Harold
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 11 p. 3551 - 3564
反应条件
1: dichloromethane / 0 - 20 °C 2: potassium hydroxide / ethanol; water / 18 h View Scheme
参考文献
Baruah, Pranjal K.; Dinsmore, Jason; King, Amber M.; Salome, Christophe; De Ryck, Marc; Kaminski, Rafal; Provins, Laurent; Kohn, Harold
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 11 p. 3551 - 3564
反应条件
1.1: tert.-butylnitrite; sodium ethanolate / ethanol / 20 h 1.2: 1 h 2.1: formic acid; zinc / methanol; water / 20 h / 20 °C 3.1: dichloromethane / 0 - 20 °C 4.1: potassium hydroxide / ethanol; water / 18 h View Scheme
参考文献
Baruah, Pranjal K.; Dinsmore, Jason; King, Amber M.; Salome, Christophe; De Ryck, Marc; Kaminski, Rafal; Provins, Laurent; Kohn, Harold
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 11 p. 3551 - 3564
