(1-溴甲基-乙烯基)-苯合成路线 （共 50 条）
反应条件
1.1: n-BuLi / tetrahydrofuran; petroleum ether / 1.5 h / 20 °C
1.2: MgBr2 / tetrahydrofuran; petroleum ether / 0.5 h / 20 °C
1.3: tetrahydrofuran; petroleum ether / 20 °C
2.1: aq. NaOH / methanol; tetrahydrofuran
View Scheme
参考文献
Zhang, Liming; Kozmin, Sergey A.
Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10204 - 10205
反应条件
trichlorosilane; N-ethyl-N,N-diisopropylamine; copper(l) chloride in diethyl ether
T=20°C;
参考文献
Nakajima, Makoto; Saito, Makoto; Hashimoto, Shunichi
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 2 p. 306 - 307
反应条件
potassium fluoride on Celite in acetonitrile
T=83°C; 6 h;
参考文献
Pace, Vittorio; Castoldi, Laura; Holzer, Wolfgang
Tetrahedron Letters, 2012 , vol. 53, # 8 p. 967 - 972
反应条件
palladium (II) trifluoroacetate; potassium hydroxide in water
T=90°C; Suzuki Coupling; 3 h; Green chemistry; Catalytic behavior; Reagent/catalyst;
参考文献
Dong, Chaonan; Zhang, Lingjuan; Xue, Xiao; Li, Huanrong; Yu, Zhiyong; Tang, Weijun; Xu, Lijin
RSC Advances, 2014 , vol. 4, # 22 p. 11152 - 11158
参考文献
Hatch; Patton
Journal of the American Chemical Society, 1954 , vol. 76, p. 2705
反应条件
1.1: indium / tetrahydrofuran; water / 16 h / 20 °C / |Inert atmosphere
1.2: 20 °C / |Inert atmosphere
2.1: Dess-Martin periodane / dichloromethane / 3 h / 0 °C / |Inert atmosphere
View Scheme
参考文献
Tripathi, Chandra Bhushan; Mukherjee, Santanu
Angewandte Chemie - International Edition, 2013 , vol. 52, # 32 p. 8450 - 8453
Angew. Chem., 2013 , vol. 125, # 32 p. 8608 - 8611,4
反应条件
Inert atmosphereReflux;
参考文献
Duan, Zheng-Chao; Hu, Xiang-Ping; Zhang, Cheng; Wang, Dao-Yong; Yu, Sai-Bo; Zheng, Zhuo
Journal of Organic Chemistry, 2009 , vol. 74, # 23 p. 9191 - 9194
反应条件
n-butyllithium in diethyl ether
T=-30°C;
参考文献
Dewar,M.J.S.; Wade,L.E.
Journal of the American Chemical Society, 1977 , vol. 99, # 13 p. 4417 - 4424
反应条件
α-methyl-β-bromostyrene in tetrahydrofuran
T=50°C; 0.5 h;
参考文献
Tokuyasu, Takahiro; Kunikawa, Shigeki; McCullough, Kevin J.; Masuyama, Araki; Nojima, Masatomo
Journal of Organic Chemistry, 2005 , vol. 70, # 1 p. 251 - 260
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / |Inert atmosphere
1.2: 16 h / 0 - 20 °C / |Inert atmosphere
2.1: sodium hydroxide / water; ethanol / 16 h / 70 °C
3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / |Inert atmosphere
3.2: 16 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Gesmundo, Nathan J.; Nicewicz, David A.
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 1272 - 1281
