2-硼-5-[[[(1,1-二甲基乙基)二甲基硅酯]氧基]甲基]-1H-吲哚-1-羧酸-1,1-二甲基乙酯合成路线 （共 4 条）
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.75 h; 2: With boric acid trimethyl ester in tetrahydrofuran T=0°C; 0.5 h;
参考文献
VERNALIS (R and D) LTD
Patent: WO2009/93012 A1, 2009 ;
Location in patent: Page/Page column 66-67 ;
WO 2009/093012 A1
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes T=-78 - 0°C;
参考文献
VERNALIS (R and D) LTD; STOKES, Stephen; FOLOPPE, Nicolas; FIUMANA, Andrea; DRYSDALE, Martin; BEDFORD, Simon; WEBB, Paul
Patent: WO2011/10083 A1, 2011 ;
Location in patent: Page/Page column 20; 28; 29 ;
WO 2011/010083 A1
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Reflux 1.2: 0.5 h / 20 °C 2.1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C 2.2: 2 h / 20 °C 3.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / -78 - 0 °C View Scheme
参考文献
VERNALIS (R and D) LTD; STOKES, Stephen; FOLOPPE, Nicolas; FIUMANA, Andrea; DRYSDALE, Martin; BEDFORD, Simon; WEBB, Paul
Patent: WO2011/10083 A1, 2011 ;
WO 2011/010083 A1
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C 1.2: 2 h / 20 °C 2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / -78 - 0 °C View Scheme
参考文献
VERNALIS (R and D) LTD; STOKES, Stephen; FOLOPPE, Nicolas; FIUMANA, Andrea; DRYSDALE, Martin; BEDFORD, Simon; WEBB, Paul
Patent: WO2011/10083 A1, 2011 ;
WO 2011/010083 A1
