O-(4-硝基苯基)羟胺合成路线 （共 24 条）
反应条件
acetic acid T=70 - 100°C; 17 h;
参考文献
CAMBREX KARLSKOGA AB; HANSSON, Lars, O.; BERGH, Anders; ELKUND, Lars
Patent: WO2010/116140 A1, 2010 ;
Location in patent: Page/Page column 48 ;
反应条件
1: 1-cyclopropyl-6,7-difluoro-8-methoxy-1H-quinazoline-2,4-dione With sodium hydride in 1,4-dioxane; N,N-dimethyl-formamide; mineral oil T=2 - 72°C; 2: O-(4-nitrophenyl)hydroxylamine in 1,4-dioxane; N,N-dimethyl-formamide; mineral oil T=72°C; 20 h; Reagent/catalystTemperatureTime;
参考文献
Boyles, David C.; Curran, Timothy T.; Parlett IV, Roger V.; Davis, Mark; Mauro, Frank
Organic Process Research and Development, 2002 , vol. 6, # 3 p. 230 - 233
反应条件
potassium carbonate in 1,4-dioxane; N,N-dimethyl-formamide T=70 - 72°C; 20 h;
参考文献
Beylin, Vladimir; Boyles, David C.; Curran, Timothy T.; Macikenas, Dainius; Parlett IV, Roger V.; Vrieze, Derek
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 441 - 449
反应条件
1: pyridine / Ambient temperature
2: 41 percent / TFA, TFSA / 20 h / Ambient temperature
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参考文献
Endo, Yasuyuki; Shudo, Koichi; Okamoto, Toshihiko
Journal of the American Chemical Society, 1982 , vol. 104, # 23 p. 6393 - 6397
