1: diethyl carboxymethylphosphonate With n-butyllithium in tetrahydrofuran T=-65°C; 0.75 h; 2: phenylpropargyl aldehyde in tetrahydrofuran T=-65 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; water pH=1.0;
参考文献
ERRANT GENE THERAPEUTICS, INC.
Patent: WO2006/52916 A2, 2006 ;
Location in patent: Page/Page column 18 ;
potassium hydroxide in 1,4-dioxane; water T=20°C; Inert atmosphere;
参考文献
Rao, Weidong; Koh, Ming Joo; Li, Dan; Hirao, Hajime; Chan, Philip Wai Hong
Journal of the American Chemical Society, 2013 , vol. 135, # 21 p. 7926 - 7932