4-(甲氧基羰基)-2-硝基苯乙酸甲酯合成路线 （共 10 条）
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=-10°C;
参考文献
Roth, Gerald J.; Heckel, Armin; Colbatzky, Florian; Handschuh, Sandra; Kley, Joerg; Lehmann-Lintz, Thorsten; Lotz, Ralf; Tontsch-Grunt, Ulrike; Walter, Rainer; Hilberg, Frank
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4466 - 4480
反应条件
thionyl chloride in tetrachloromethane T=20°C; 4 h;
参考文献
Schaper, Klaus; Abdollah Madani Mobarekeh; Grewer, Christof
European Journal of Organic Chemistry, 2002 , # 6 p. 1037 - 1046
反应条件
hydrogenchloride in N-methyl-acetamide; water
参考文献
Roth, Gerald Juergen; Heckel, Armin; Lehmann-Lintz, Thorsten; Kley, Joerg; Hilberg, Frank; Van Meel, Jacobus
Patent: US2003/92756 A1, 2003 ;
反应条件
1: 86 percent / Br2 / benzene / 2 h / Irradiation 2: 74 percent / ethanol; H2O / 3 h / Heating 3: 87 percent / sulfuric acid / H2O / 5 °C 4: 70 percent / nitric acid; sulfuric acid / 3 h / 20 °C 5: 70 percent / thionylchloride / CCl4 / 4 h / 20 °C View Scheme
参考文献
Schaper, Klaus; Abdollah Madani Mobarekeh; Grewer, Christof
European Journal of Organic Chemistry, 2002 , # 6 p. 1037 - 1046
反应条件
1: 74 percent / ethanol; H2O / 3 h / Heating 2: 87 percent / sulfuric acid / H2O / 5 °C 3: 70 percent / nitric acid; sulfuric acid / 3 h / 20 °C 4: 70 percent / thionylchloride / CCl4 / 4 h / 20 °C View Scheme
参考文献
Schaper, Klaus; Abdollah Madani Mobarekeh; Grewer, Christof
European Journal of Organic Chemistry, 2002 , # 6 p. 1037 - 1046
反应条件
1: 70 percent / nitric acid; sulfuric acid / 3 h / 20 °C 2: 70 percent / thionylchloride / CCl4 / 4 h / 20 °C View Scheme
参考文献
Schaper, Klaus; Abdollah Madani Mobarekeh; Grewer, Christof
European Journal of Organic Chemistry, 2002 , # 6 p. 1037 - 1046
反应条件
1: 87 percent / sulfuric acid / H2O / 5 °C 2: 70 percent / nitric acid; sulfuric acid / 3 h / 20 °C 3: 70 percent / thionylchloride / CCl4 / 4 h / 20 °C View Scheme
参考文献
Schaper, Klaus; Abdollah Madani Mobarekeh; Grewer, Christof
European Journal of Organic Chemistry, 2002 , # 6 p. 1037 - 1046
反应条件
1: diethyl ether 2: glacial acetic acid; water; concentrated sulfuric acid 3: sulfuric acid View Scheme
参考文献
Borsche; Stackmann; Makaroff-Semljanski
Chemische Berichte, 1916 , vol. 49, p. 2230
反应条件
1: glacial acetic acid; water; concentrated sulfuric acid 2: sulfuric acid View Scheme
参考文献
Borsche; Stackmann; Makaroff-Semljanski
Chemische Berichte, 1916 , vol. 49, p. 2230
反应条件
hydrogen; acetic acid; palladium 10 on activated carbon T=20°C; P=2585.81 Torr; 2.5 h;
参考文献
Roth, Gerald J.; Heckel, Armin; Colbatzky, Florian; Handschuh, Sandra; Kley, Joerg; Lehmann-Lintz, Thorsten; Lotz, Ralf; Tontsch-Grunt, Ulrike; Walter, Rainer; Hilberg, Frank
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4466 - 4480
