bis(triphenylphosphine)palladium(II)-chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; sodium iodide in N,N-dimethyl acetamide T=115°C; 16 h; further reagents: LiCl, LiBr, LiI; various CO pressure (5-95 psig);

pyridine; 1-methyl-pyrrolidin-2-one T=160°C; Acylation; 3 h;

1: 1.) pyridine, 2.) acetic anhydride / 1) N,N-dimethylacetamide, 70 deg C, 1 h; 2) N,N-dimethylacetamide, 80 deg C, 4 h 2: 82 percent / bis(triphenylphosphine)palladium(II) chloride, PPh3, NaI, 1,8-diazabicyclo<5.4.0>undec-7-ene / N,N-dimethyl-acetamide / 16 h / 115 °C / further reagents: LiCl, LiBr, LiI; various CO pressure (5-95 psig) View Scheme

1: 1.) pyridine, 2.) acetic anhydride / 1) N,N-dimethylacetamide, 70 deg C, 1 h; 2) N,N-dimethylacetamide, 80 deg C, 4 h 2: 82 percent / bis(triphenylphosphine)palladium(II) chloride, PPh3, NaI, 1,8-diazabicyclo<5.4.0>undec-7-ene / N,N-dimethyl-acetamide / 16 h / 115 °C / further reagents: LiCl, LiBr, LiI; various CO pressure (5-95 psig) View Scheme