4-甲基-3(2H)-哒嗪酮合成路线 （共 10 条）
反应条件
bromine in acetic acid T=50 - 80°C; 2 h;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2004/74290 A1, 2004 ;
Location in patent: Page 78-79 ;
WO 2004/074290 A1
反应条件
(SPY-5-31)-dichloro-(κ2(C,O)-(2-isopropyloxybenzylidene))(1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene)ruthenium in dichloromethane T=40°C; 36 h; Sealed tubeInert atmosphere;
参考文献
Donohoe, Timothy J.; Fishlock, Lisa P.; Basutto, Jose A.; Bower, John F.; Procopiou, Panayiotis A.; Thompson, Amber L.
Chemical Communications, 2009 , # 21 p. 3008 - 3010
参考文献
McNab, Hamish
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 1203 - 1208
反应条件
1: hydrazine hydrate / ethanol / 4 h / Heating 2: 1.) Br2, 2.) NaOAc / 1.) AcOH, 80 deg C, 2 h, 2.) AcOH, reflux, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 2 p. 239 - 249
反应条件
1: NaOH, H2O / ethanol / 50 °C 2: hydrazine hydrate / ethanol / 4 h / Heating 3: 1.) Br2, 2.) NaOAc / 1.) AcOH, 80 deg C, 2 h, 2.) AcOH, reflux, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 2 p. 239 - 249
反应条件
1: bromine; acetic acid 2: Erhitzen unter vermindertem Druck View Scheme
参考文献
Journal of the American Chemical Society, , vol. 78, p. 407,408
反应条件
hydrazine hydrate 6 h; Heating;
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 3-4 p. 129 - 132
反应条件
1: phosphorus oxychloride / 4 h / 85 - 95 °C 2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C 3: H2 / Raney Ni / methanol / 20 °C / 760 Torr View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
反应条件
trichlorophosphate T=90°C; 3 h;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2004/74290 A1, 2004 ;
Location in patent: Page 79 ;
WO 2004/074290 A1
反应条件
1: phosphorus oxychloride / 4 h / 85 - 95 °C
2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C
View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
