2-(4-氯苯基)-4-三氟甲基-1H-咪唑合成路线 (共 1 条)
反应条件
1: 3,3-dibromo-1,1,1-trifluoropropanone With sodium acetate Hydrolysis; 0.5 h; Heating; 2: 4-chlorobenzaldehyde With ammonium hydroxide in methanol T=20°C; cyclocondensation; 20 h;
参考文献
Dhainaut, Alain; Tizot, Andre; Raimbaud, Eric; Lockhart, Brian; Lestage, Pierre; Goldstein, Solo
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2165 - 2175