1: 3,3-dibromo-1,1,1-trifluoropropanone With sodium acetate Hydrolysis; 0.5 h; Heating; 2: pyridine-4-carbaldehyde With ammonium hydroxide in methanol T=20°C; cyclocondensation; 20 h;

triethylamine in methanol 72 h; Ambient temperatureIrradiation;

1: 84 percent / aq. NH3 / methanol / 24 h / 60 °C 2: 55 percent / DIBALH / tetrahydrofuran; toluene / -78 - 0 °C View Scheme