2-氧代-1,2,3,4-四氢嘧啶-5-羧酸乙酯合成路线 （共 13 条）
反应条件
hydrogenchloride in ethanol; water Reflux;
参考文献
CURIS, INC.
Patent: WO2009/36016 A1, 2009 ;
Location in patent: Page/Page column 69 ;
反应条件
hydrogenchloride in ethanol Heating;
参考文献
Ohta, Kiminori; Kawachi, Emiko; Inoue, Noriko; Fukasawa, Hiroshi; Hashimoto, Yuichi; Itai, Akiko; Kagechika, Hiroyuki
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1504 - 1513
反应条件
hydrogenchloride in ethanol Heating / reflux;
参考文献
Qian, Changgeng; Cai, Xiong; Zhai, Haixiao
Patent: US2009/76006 A1, 2009 ;
Location in patent: Page/Page column 31; 40 ;
US 20090076006 A1
反应条件
hydrogenchloride in ethanol; water T=30°C; 2 h; Reflux;
参考文献
Leclerc, Jean-Philippe; Li, Chun Sing; Ramtohul, Yeeman K.
Patent: US2011/152295 A1, 2011 ;
Location in patent: Page/Page column 24 ;
反应条件
1.1: Na; EtOH / benzene / 2 h / 0 °C 1.2: 58 percent / benzene / 3 h / 50 °C 2.1: 66 percent / aq. HCl / ethanol / Heating View Scheme
参考文献
Leclerc, Jean-Philippe; Li, Chun Sing; Ramtohul, Yeeman K.
Patent: US2011/152295 A1, 2011 ;
反应条件
1.1: bromine; acetic acid / 15 h / 20 - 110 °C 1.2: 2 h / pH 4 2.1: trichlorophosphate / 2 h / 117 °C / Cooling with ice 3.1: sodium hydroxide; water / tetrahydrofuran / 1.5 h 3.2: 1 h / pH 1.5 - 4 4.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Leclerc, Jean-Philippe; Li, Chun Sing; Ramtohul, Yeeman K.
Patent: US2011/152295 A1, 2011 ;
反应条件
1: Br2; AcOH / 1.5 h / Heating 2: POCl3; N,N-dimethylaniline / 1.5 h / Heating View Scheme
参考文献
CURIS, INC.; BAO, Rudi; LAI, Chengjung; QIAN, Changgeng
Patent: WO2011/130628 A1, 2011 ;
WO 2011/130628 A1
反应条件
bromine; acetic acid 1.5 h; Heating / reflux;
参考文献
Qian, Changgeng; Cai, Xiong; Zhai, Haixiao
Patent: US2009/76006 A1, 2009 ;
Location in patent: Page/Page column 31; 40 ;
US 20090076006 A1
反应条件
1: Br2; AcOH / 1.5 h / Heating 2: POCl3; N,N-dimethylaniline / 1.5 h / Heating 3: ethanolic NH3 / 1 h / 100 °C View Scheme
参考文献
Ohta, Kiminori; Kawachi, Emiko; Inoue, Noriko; Fukasawa, Hiroshi; Hashimoto, Yuichi; Itai, Akiko; Kagechika, Hiroyuki
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1504 - 1513
反应条件
1.1: bromine; acetic acid / 15 h / 20 - 110 °C 1.2: 2 h / pH 4 2.1: trichlorophosphate / 2 h / 117 °C / Cooling with ice 3.1: sodium hydroxide; water / tetrahydrofuran / 1.5 h 3.2: 1 h / pH 1.5 - 4 4.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C 5.1: ammonia / 1,4-dioxane / 0.75 h / 20 °C 6.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1.08 h / 0 - 20 °C View Scheme
参考文献
Leclerc, Jean-Philippe; Li, Chun Sing; Ramtohul, Yeeman K.
Patent: US2011/152295 A1, 2011 ;
