sodium perchlorate in methanol; acetone T=4°C; Inert atmosphere;

Lilt;Co(I)Pcgt;*4.5THF in acetonitrile 48 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

1: N,N'-dicyclohexyl-4-morpholinecarboxamidinium salt of adenosine-5'-phosphoromorpholidate; dTMP disodium salt With 1H-tetrazole; MgCl2*6H2O; water T=20°C; 1.5 h; in ball mill; 2: triethylammonium bicarbonate in water; acetonitrile pH=8.2;

Dowex-50W ion exchange column (H+ form) Inert atmosphere;