2-乙基苯并呋喃-3-基 4-甲氧基苯基甲酮合成路线 （共 9 条）
反应条件
tin(IV) chloride in carbon disulfide T=5 - 20°C; Inert atmosphereCooling with ice;
参考文献
J-PHARMA CO., LTD.; WEMPE, Michael, F.; ENDOU, Hitoshi
Patent: WO2012/48058 A2, 2012 ;
Location in patent: Page/Page column 14 ;
WO 2012/048058 A2
反应条件
iron(III) chloride in water; toluene
参考文献
Sanofi
Patent: US4766223 A1, 1988 ;
反应条件
1: diethylene glycol; hydrazine hydrate / anschliessend mit Kaliumhydroxid 2: tin (IV)-chloride; carbon disulfide View Scheme
参考文献
Wempe; Quade; Jutabha; Iwen; Frick; Rice; Wakui; Endou
Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 12 p. 1312 - 1323
反应条件
1: benzene 2: diethylene glycol; hydrazine hydrate / anschliessend mit Kaliumhydroxid 3: tin (IV)-chloride; carbon disulfide View Scheme
参考文献
Wempe; Quade; Jutabha; Iwen; Frick; Rice; Wakui; Endou
Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 12 p. 1312 - 1323
反应条件
1.1: potassium carbonate / acetone / 6 h / Reflux 2.1: hydrazine / water; diethylene glycol / 120 - 190 °C 2.2: 6 h / 120 - 130 °C 3.1: carbon disulfide / 0.5 h / Inert atmosphere; Cooling with ice 3.2: 6 h / 20 °C / Cooling with ice View Scheme
参考文献
J-PHARMA CO., LTD.; WEMPE, Michael, F.; ENDOU, Hitoshi
Patent: WO2012/48058 A2, 2012 ;
WO 2012/048058 A2
反应条件
1: pyridine hydrochloride 2: aqueous acetic acid; bromine View Scheme
参考文献
J-PHARMA CO., LTD.; WEMPE, Michael, F.; ENDOU, Hitoshi
Patent: WO2012/48058 A2, 2012 ;
WO 2012/048058 A2
反应条件
1: With ethyl mercaptan sodium salt in N,N-dimethyl-formamide T=125 - 130°C; 1 h; 2: With water; ammonium chloride in N,N-dimethyl-formamide
参考文献
J-PHARMA CO., LTD.; WEMPE, Michael, F.; ENDOU, Hitoshi
Patent: WO2012/48058 A2, 2012 ;
Location in patent: Page/Page column 14-15 ;
WO 2012/048058 A2
反应条件
(i) aq. NaOH, (ii) /BRN= 969135/; Multistep reaction;
参考文献
Royer,R.; Bisagni,E.
Bulletin de la Societe Chimique de France, 1960 , p. 395 - 399
反应条件
1: pyridine hydrochloride
2: aqueous acetic acid; bromine
3: ethanolic KOH-solution
View Scheme
参考文献
J-PHARMA CO., LTD.; WEMPE, Michael, F.; ENDOU, Hitoshi
Patent: WO2012/48058 A2, 2012 ;
WO 2012/048058 A2
