(S)-(-)-3-羟基-3-苯基丙酸乙酯合成路线 （共 48 条）
反应条件
sodium hydroxide 1.) water, rt; 2.) ether, 0 deg C, 15 min; Multistep reaction;
参考文献
Bernardi, Anna; Colombo, Lino; Gennari, Cesare; Prati, Laura
Tetrahedron, 1984 , vol. 40, # 19 p. 3769 - 3776
反应条件
1: 78 percent / H2O 2: 98 percent / LiAlH4 / diethyl ether 3: 95 percent / CH2Cl2 4: Ph3P, DEAD / diethyl ether 5: 89 percent / HCl / ethanol View Scheme
参考文献
Kumar, Ashok; Ner, Dilip H.; Dike, Suneel Y.
Tetrahedron Letters, 1991 , vol. 32, # 16 p. 1901 - 1904
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 0.75 h;
参考文献
Kamal, Ahmed; Khanna; Ramu
Tetrahedron Asymmetry, 2002 , vol. 13, # 18 p. 2039 - 2051
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 19 h / 0 - 20 °C / |Inert atmosphere 2: hydrogenchloride / water / 1 h / |Reflux View Scheme
参考文献
Varga, Annamaria; Zaharia, Valentin; Nogradi, Mihaly; Poppe, Laszlo
Tetrahedron Asymmetry, 2013 , vol. 24, # 21-22 p. 1389 - 1394
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 19 h / 0 - 20 °C / |Inert atmosphere 2: hydrogenchloride / water / 1 h / |Reflux View Scheme
参考文献
Varga, Annamaria; Zaharia, Valentin; Nogradi, Mihaly; Poppe, Laszlo
Tetrahedron Asymmetry, 2013 , vol. 24, # 21-22 p. 1389 - 1394
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 19 h / 0 - 20 °C / |Inert atmosphere 2: hydrogenchloride / water / 1 h / |Reflux View Scheme
参考文献
Varga, Annamaria; Zaharia, Valentin; Nogradi, Mihaly; Poppe, Laszlo
Tetrahedron Asymmetry, 2013 , vol. 24, # 21-22 p. 1389 - 1394
反应条件
1: 70 percent / tetrahydrofuran; H2O / 70 °C 2: 90 percent / LiAlH4 / tetrahydrofuran / 0 - 25 °C View Scheme
参考文献
Chenevert, Robert; Fortier, Genevieve; Rhlid, Rachid Bel
Tetrahedron, 1992 , vol. 48, # 33 p. 6769 - 6776
反应条件
1: 80 percent / LiAlH4 / diethyl ether / Ambient temperature 2: 85 percent / Et3N / diethyl ether / 2 h / 0 °C 3: 65 percent / Ph3P, diethyl azodicarboxylate (DEAD) / diethyl ether / 4 h / -10 °C 4: 90 percent / NaI / acetone / Heating 5: 85 percent / tetrahydrofuran; H2O / Ambient temperature 6: HCl / diethyl ether View Scheme
参考文献
Chenevert, Robert; Fortier, Genevieve
Chemistry Letters, 1991 , p. 1603 - 1606
