反应条件
1.1: 97 percent / aq. NaOH / 6 h / 100 °C 2.1: 98 percent / dimethylformamide / 4 h / 24 °C 3.1: 98 percent / Et3N; DMAP / CH2Cl2 / 3.5 h / 20 - 40 °C 4.1: 95 percent / hydrogen / Pd/C / methanol / 3 h / 30 °C 5.1: 40 percent / polyphosphoric acid / toluene / 11 h / 110 °C 6.1: aq. Na2CO3 / methanol; H2O / 0.5 h / 23 °C 7.1: CH2Cl2 / 17 h / 25 °C 7.2: 70 percent / H2O View Scheme
参考文献
Fuenfschilling, Peter C.; Zaugg, Werner; Beutler, Ulrich; Kaufmann, Daniel; Lohse, Olivier; Mutz, Jean-Paul; Onken, Ulrich; Reber, Jean-Louis; Shenton, David
Organic Process Research and Development, 2005 , vol. 9, # 3 p. 272 - 277