N-(3-甲氧基苯基)-beta-丙氨酸合成路线 （共 8 条）
参考文献
Kasiotis, Konstantinos M.; Fokialakis, Nikolas; Haroutounian, Serkos A.
Synthesis, 2006 , # 11 p. 1791 - 1802
反应条件
in acrylic acid; toluene
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US5693647 A1, 1997 ;
反应条件
sodium hydroxide in ethanol Heating;
参考文献
Booker-Milburn, Kevin I.; Dunkin, Ian R.; Kelly, Frances C.; Khalaf, Abedawn I.; Learmonth, David A.; Proctor, George R.; Scopes, David I. C.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 21 p. 3261 - 3273
反应条件
1: polyphosphoric acid / 110 °C 2: DMAP / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Edwards, James P.; Higuchi, Robert I.; Winn, David T.; Pooley, Charlotte L. F.; Caferro, Thomas R.; Hamann, Lawrence G.; Zhi, Lin; Marschke, Keith B.; Goldman, Mark E.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 1003 - 1008
反应条件
1: polyphosphoric acid / 110 °C 2: DMAP / tetrahydrofuran / Ambient temperature 3: 1.) LiAlH4, 2.) H2, AcOH / 2) Pd/C / 1.) from 0 deg C to RT, 2.) EtOAC, EtOH 4: BBr3 / CH2Cl2 / -78 - 0 °C View Scheme
参考文献
Edwards, James P.; Higuchi, Robert I.; Winn, David T.; Pooley, Charlotte L. F.; Caferro, Thomas R.; Hamann, Lawrence G.; Zhi, Lin; Marschke, Keith B.; Goldman, Mark E.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 1003 - 1008
参考文献
Kasiotis, Konstantinos M.; Fokialakis, Nikolas; Haroutounian, Serkos A.
Synthesis, 2006 , # 11 p. 1791 - 1802
反应条件
PPA
1.) r.t., 0.5 h; 60 deg C, overnight, 2.) 70-80 deg C, 2 h; 100 deg C, 1 h; Yield given. Yields of byproduct given;
参考文献
Booker-Milburn, Kevin I.; Dunkin, Ian R.; Kelly, Frances C.; Khalaf, Abedawn I.; Learmonth, David A.; Proctor, George R.; Scopes, David I. C.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 21 p. 3261 - 3273
反应条件
1: polyphosphoric acid / 110 °C
2: DMAP / tetrahydrofuran / Ambient temperature
3: 1.) LiAlH4, 2.) H2, AcOH / 2) Pd/C / 1.) from 0 deg C to RT, 2.) EtOAC, EtOH
4: BBr3 / CH2Cl2 / -78 - 0 °C
5: ZnCl2 / ethanol / 110 - 120 °C
View Scheme
参考文献
Edwards, James P.; Higuchi, Robert I.; Winn, David T.; Pooley, Charlotte L. F.; Caferro, Thomas R.; Hamann, Lawrence G.; Zhi, Lin; Marschke, Keith B.; Goldman, Mark E.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 1003 - 1008
