1 -苯基- 5 -（三氟甲基）- 1H -吡唑合成路线 （共 7 条）
反应条件
carbon dioxide T=65°C; P=90009 Torr; 0.75 h; TemperaturePressure;
参考文献
Rossatto, Marcelo; Casanova, Caroline; Lima, Ana P.; Emmerich, Daniel J.; Oliveira, Vladimir; Dallago, Rogerio M.; Frizzo, Clarissa P.; Moreira, Dayse N.; Buriol, Lilian; Brondani, Sergio; Zanatta, Nilo; Bonacorso, Helio G.; Martins, Marcos A. P.
Arkivoc, 2014 , vol. 2014, # 2 p. 224 - 232
反应条件
1: in ethanol 2 h; Heating; 2: With hydrogenchloride in dichloromethane T=25°C; 1 h; Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
sulfuric acid in methanol T=60°C; 24 h; Overall yield = 50 percent; regioselective reaction;
参考文献
Bonacorso, Helio G.; Correa, Michele S.; Porte, Liliane M.F.; Pittaluga, Everton P.; Zanatta, Nilo; Martins, Marcos A.P.
Tetrahedron Letters, 2012 , vol. 53, # 41 p. 5488 - 5491
反应条件
1-n-butyl-3-methylimidazolium tetrafluoroborate T=25°C; 1 - 3 h;
参考文献
Buriol, Lilian; Frizzo, Clarissa P.; Marzari, Mara R. B.; Moreira, Dayse N.; Prola, Lizie D. T.; Zanatta, Nilo; Bonacorso, Helio G.; Martins, Marcos A. P.
Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 6 p. 1037 - 1044
反应条件
in toluene T=86°C; 0.05 h; IrradiationMicrowave; Title compound not separated from byproducts.;
参考文献
Martins, Marcos A. P.; Pereira, Claudio M. P.; Moura, Sidnei; Frizzo, Clarissa P.; Beck, Paulo; Zanatta, Nilo; Bonacorso, Helio G.; Flores, Alex F. C.
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 5 p. 1195 - 1199
反应条件
1: 1-phenyl-5-trifluoromethyl-1H-pyrazole With n-butyllithium; N,N,N',N'',N''-pentamethyldiethylenetriamine; diisopropylamine in tetrahydrofuran; hexane T=-75°C; 0.0833333 h; 2: carbon dioxide Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1: 52 percent / diisopropylamine; N,N,N',N",N"-pentamethyldiethylenetriamine; butyllithium / tetrahydrofuran; hexane / 0.08 h / -75 °C
2: 14 percent / diisopropylamine; N,N,N',N",N"-pentamethyldiethylenetriamine; butyllithium / tetrahydrofuran; hexane / 0.08 h / -75 °C
View Scheme
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
