1-二苯甲基-3-甲烷磺酸氮杂环丁烷合成路线 （共 34 条）
反应条件
1: 81 percent / NaBH4 / dimethylformamide / 3 h / 100 °C 2: 1.) 10percent HCl, 2.) H2 / 1.) methanol, 2.) 20percent Pd(OH)2 / C, 3 atm, 3h View Scheme
参考文献
Heterocycles, , vol. 24, # 9 p. 2467 - 2470
反应条件
sodium tetrahydroborate in N,N-dimethyl-formamide T=100°C; 3 h;
参考文献
Nitta, Yoshihiro; Kanamori, Yasuyuki
Heterocycles, 1986 , vol. 24, # 9 p. 2467 - 2470
反应条件
potassium iodide in ethylene glycol dimethyl ether; water T=20°C; Reflux;
参考文献
WO2011/61214 A1, ;
Page/Page column 159-160 ;
WO 2011/061214 A1
反应条件
1,3,5-trishydroxybenzene; sodium iodide; sodium nitrite in water; N,N-dimethyl-formamide T=50°C; 48 h;
参考文献
Journal of Organic Chemistry, , vol. 55, # 9 p. 2920 - 2924
反应条件
1: With 1-chloroethyl chlorocarbonate in dichloromethane 2.5 h; Heating / reflux; 2: With methanol 2.5 h; Heating / reflux;
参考文献
PFIZER LIMITED
Patent: WO2007/34325 A1, 2007 ;
Location in patent: Page/Page column 59-60 ;
WO 2007/034325 A1
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; acetonitrile 30 h; Heating / reflux;
参考文献
UCB, S.A.
Patent: WO2003/87064 A1, 2003 ;
Location in patent: Page/Page column 36 ;
WO 03/087064 A1
反应条件
1,3,5-trishydroxybenzene; sodium iodide; sodium nitrite in water; N,N-dimethyl-formamide T=50°C; 48 h;
参考文献
Archibald, T. G.; Gilardi, Richard; Baum, K.; George, Clifford
Journal of Organic Chemistry, 1990 , vol. 55, # 9 p. 2920 - 2924
反应条件
1: 3,4-dichloro-phenol With sodium hydride in DMF (N,N-dimethyl-formamide) 0.166667 h; 2: 1-benzhydryl-3-methanesulfonyloxyazetidine in DMF (N,N-dimethyl-formamide) T=60°C; 20 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/26113 A1, 2005 ;
Location in patent: Page 52-53 ;
WO 2005/026113 A1
反应条件
methylmagnesium bromide in tetrahydrofuran; diethyl ether T=0°C; 1.5 h;
参考文献
WO2004/112793 A1, ;
Page/Page column 126 ;
反应条件
lithium carbonate; lithium bromide in tetrahydrofuran
参考文献
Carruthers, Nicholas I.; Wong, Shing-Chun; Chan, Tze-Ming
Journal of Chemical Research - Part S, 1996 , # 9 p. 430 - 431
