1-二苯甲基-3-甲烷磺酸氮杂环丁烷合成路线 （共 34 条）
反应条件
triethylamine in dichloromethane T=0°C; 2 h;
参考文献
FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis
Patent: WO2011/61214 A1, 2011 ;
Location in patent: Page/Page column 85-86 ;
WO 2011/061214 A1
反应条件
triethylamine in dichloromethane T=0 - 20°C; Product distribution / selectivity;
参考文献
Pfizer Inc.
Patent: US2010/190771 A1, 2010 ;
Location in patent: Page/Page column 28-29 ;
反应条件
pyridine T=0 - 20°C;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1591443 A1, 2005 ;
Location in patent: Page/Page column 67 ;
反应条件
in pyridine; dichloromethane; Petroleum ether
参考文献
Eli Lilly and Company
Patent: US5545636 A1, 1996 ;
US 5545636 A
反应条件
1: 51 percent / methanol / 1) 25 deg C, 7d, 2) 50 deg C, 7d, 3) 25 deg C, 18d 2: NEt3 / benzene View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 24 p. 6729 - 6730
反应条件
1: N-ethyl-N,N-diisopropylamine / ethanol / 0 - 90 °C 2: triethylamine / dichloromethane / 1 h / 0 °C View Scheme
参考文献
WO2013/14448 A1, ;
WO 2013/014448 A1
参考文献
Heterocycles, , vol. 75, # 12 p. 2981 - 2988
反应条件
1: water; N,N-dimethyl-formamide / 90 °C 2: sulfuric acid / 2 h / 90 °C View Scheme
参考文献
Morley, Andrew; Tomkinson, Nicholas; Cook, Andrew; MacDonald, Catherine; Weaver, Richard; King, Sarah; Jenkinson, Lesley; Unitt, John; McCrae, Christopher; Phillips, Tim
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 20 p. 6031 - 6035
反应条件
in water; N,N-dimethyl-formamide T=65°C; 9 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2119706 A1, 2009 ;
Location in patent: Page/Page column 48 ;
EP 2119706 A1
