5-(4-硝基苯基)异噁唑-3-羧酸合成路线 （共 15 条）
参考文献
Gazzetta Chimica Italiana, , vol. 69, p. 214,218
反应条件
1: pyridine / 12 h / 0 - 20 °C 2: DIPEA / Pd(PPh3)2Cl2; CuI / dimethylformamide / 48 h / 45 °C 3: aq. NaOH / diethyl ether; methanol / 18 h 4: CuSO4; sodium ascorbate; KHCO3 / 2-methyl-propan-2-ol; H2O / 24 h / 50 °C 5: aq. NaOH / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 31 p. 9613 - 9615
反应条件
1: DIPEA / Pd(PPh3)2Cl2; CuI / dimethylformamide / 48 h / 45 °C 2: aq. NaOH / diethyl ether; methanol / 18 h 3: CuSO4; sodium ascorbate; KHCO3 / 2-methyl-propan-2-ol; H2O / 24 h / 50 °C 4: aq. NaOH / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 31 p. 9613 - 9615
反应条件
1: CuSO4; sodium ascorbate; KHCO3 / 2-methyl-propan-2-ol; H2O / 24 h / 50 °C 2: aq. NaOH / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 31 p. 9613 - 9615
反应条件
1: aq. NaOH / diethyl ether; methanol / 18 h 2: CuSO4; sodium ascorbate; KHCO3 / 2-methyl-propan-2-ol; H2O / 24 h / 50 °C 3: aq. NaOH / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 31 p. 9613 - 9615
反应条件
sodium hydroxide in tetrahydrofuran; water T=60°C; 1 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 16 p. 4521 - 4524
反应条件
1: hydroxylamine hydrochloride / methanol / 3 h / |Reflux 2: sodium hydroxide / tetrahydrofuran / 1 h / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 273 - 280
反应条件
1: sodium methylate / tetrahydrofuran / 8 h / 20 °C 2: hydroxylamine hydrochloride / methanol / 3 h / |Reflux 3: sodium hydroxide / tetrahydrofuran / 1 h / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 273 - 280
参考文献
Gazzetta Chimica Italiana, , vol. 69, p. 214,218
反应条件
1: copper-powder; ethanol; N2H4+H2O View Scheme
参考文献
Cusmano
Gazzetta Chimica Italiana, 1940 , vol. 70, p. 240,244
