5-(4-甲基苯基)异噻唑-3-羧酸合成路线 （共 8 条）
反应条件
1: With sodium hydroxide in ethanol T=20°C; 24 h; 2: With hydrogenchloride in water pH=2;
参考文献
Andrzejak, Virginie; Muccioli, Giulio G.; Body-Malapel, Mathilde; El Bakali, Jamal; Djouina, Madjid; Renault, Nicolas; Chavatte, Philippe; Desreumaux, Pierre; Lambert, Didier M.; Millet, Regis
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 12 p. 3777 - 3786
反应条件
potassium hydroxide in ethanol; water Reflux;
参考文献
Potkin; Gadzhily; Dikusar; Petkevich; Zhukovskaya; Aliev; Nagieva
Russian Journal of Organic Chemistry, 2012 , vol. 48, # 1 p. 127 - 136
反应条件
sodium hydroxide in tetrahydrofuran T=60°C; 1 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 273 - 280
反应条件
1.1: sodium ethanolate / ethanol / 2 h / Reflux 1.2: 1 h 2.1: hydroxylamine hydrochloride / ethanol / 2 h / Reflux 3.1: sodium hydroxide / ethanol / 24 h / 20 °C 3.2: pH 2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 12 p. 3777 - 3786
反应条件
1.1: hydroxylamine hydrochloride / ethanol / 2 h / Reflux 2.1: sodium hydroxide / ethanol / 24 h / 20 °C 2.2: pH 2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 12 p. 3777 - 3786
反应条件
1: pyridine; acetic anhydride / 7 h / 90 - 95 °C 2: potassium hydroxide / ethanol; water / Reflux View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 48, # 1 p. 127 - 136
反应条件
1: hydroxylamine hydrochloride / methanol / 3 h / |Reflux 2: sodium hydroxide / tetrahydrofuran / 1 h / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 273 - 280
反应条件
thionyl chloride; N,N-dimethyl-formamide
3 h;
参考文献
Potkin; Petkevich; Kletskov; Dikusar; Zubenko; Zhukovskaya; Kazbanov; Pashkevich
Russian Journal of Organic Chemistry, 2013 , vol. 49, # 10 p. 1523 - 1533
Zh. Org. Khim., 2013 , vol. 49, # 10 p. 1543 - 1553,11
