5-氯-2-(甲基氨基)苯甲酸合成路线 （共 8 条）
反应条件
potassium phosphate; copper(l) iodide; 1,1'-binaphthyl-2,2'-diol in N,N-dimethyl-formamide T=25°C; Ullmann reaction; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Zeng, Liang; Fu, Hua; Qiao, Renzhong; Jiang, Yuyang; Zhao, Yufen
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1671 - 1676
反应条件
1: With dihydrogen peroxide; sodium hydroxide in water T=30°C; Cooling with ice; 2: With acetic acid in water pH=5 - 6; Cooling with ice;
参考文献
Wang, Yao; Zhang, Mei; Cao, Shengli; Lin, Huihui; Gao, Man; Li, Zhongfeng
Synthetic Communications, 2012 , vol. 42, # 18 p. 2715 - 2727
反应条件
sodium hydride in N,N-dimethyl-formamide 1) 0-5 deg C, 15 min, 2) r.t. 18 h;
参考文献
Coppola, Gary M.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1785 - 1787
反应条件
sodium carbonate in water
参考文献
Gates, Marshall
Journal of Organic Chemistry, 1980 , vol. 45, # 9 p. 1675 - 1681
反应条件
1: 85.2 percent / Na2CO3 / dimethylformamide 2: 7 percent / Na2CO3 / H2O View Scheme
参考文献
Gates, Marshall
Journal of Organic Chemistry, 1980 , vol. 45, # 9 p. 1675 - 1681
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide 2.1: dihydrogen peroxide; sodium hydroxide / water / 30 °C / Cooling with ice 2.2: pH 5 - 6 / Cooling with ice View Scheme
参考文献
Wang, Yao; Zhang, Mei; Cao, Shengli; Lin, Huihui; Gao, Man; Li, Zhongfeng
Synthetic Communications, 2012 , vol. 42, # 18 p. 2715 - 2727
反应条件
1: sulfuric acid; sodium nitrite / 80 °C 2: tin; hydrochloric acid 3: hydrochloric acid; sodium nitrite; copper chloride View Scheme
参考文献
Keller
Archiv der Pharmazie (Weinheim, Germany), 1908 , vol. 246, p. 15,21
反应条件
1: tin; hydrochloric acid 2: hydrochloric acid; sodium nitrite; copper chloride View Scheme
参考文献
Keller
Archiv der Pharmazie (Weinheim, Germany), 1908 , vol. 246, p. 15,21
