T=110°C; P=0.001 Torr;

1: 110 °C / 0 Torr 2: aqueous HCl View Scheme

1: 110 °C / 0 Torr 2: aqueous NaOH View Scheme

1.1: 87 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C 2.1: HCl / ethyl acetate; H2O / 0.5 h 2.2: 81 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C 3.1: 80 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C 4.1: HCl / ethyl acetate; H2O / 0.5 h 4.2: 80 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C 5.1: 84 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C 6.1: HCl / ethyl acetate; H2O / 0.5 h 6.2: 77 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C 7.1: 50 percent / NaOH / methanol; H2O / 3 h / pH 8 - 9 View Scheme