6-氯-3-氰基吡啶合成路线

33252-28-76-氯-3-氰基吡啶

55676-22-72-氯-5-乙酰基吡啶

参考文献

Ciba-Geigy Corporation
Patent: US5612340 A1, 1997 ;

33252-28-76-氯-3-氰基吡啶+

917-64-6magnesium,carbanide,iodide

55676-22-72-氯-5-乙酰基吡啶

参考文献

Raeth; Schiffmann
Justus Liebigs Annalen der Chemie, 1931 , vol. 487, p. 127,129

33252-28-76-氯-3-氰基吡啶+

917-64-6magnesium,carbanide,iodide+

60-29-7乙醚

6271-78-96-氯烟酰胺+

55676-22-72-氯-5-乙酰基吡啶

参考文献

Raeth; Schiffmann
Justus Liebigs Annalen der Chemie, 1931 , vol. 487, p. 127,129

33252-28-76-氯-3-氰基吡啶

1061357-83-26-氯-4-碘烟腈

参考文献

ADAMS, Jerry Leroy; Faitg, Thomas H.; Johnson, Neil W.; Lin, Hong
Patent: US2010/113475 A1, 2010 ;
Location in patent: Page/Page column 37 ;

33252-28-76-氯-3-氰基吡啶

139585-70-92-溴-5-氰基吡啶

参考文献

PFIZER LIMITED; BURGESS, Gary
Patent: WO2012/114223 A1, 2012 ;
Location in patent: Page/Page column 56 ;
WO 2012/114223 A1

33252-28-76-氯-3-氰基吡啶+

925-90-6乙基溴化镁

3222-52-46-乙基烟腈

参考文献

NOVARTIS AG
Patent: WO2008/71404 A1, 2008 ;
Location in patent: Page/Page column 42 ;

33252-28-76-氯-3-氰基吡啶+

75-89-82,2,2-三氟乙醇

159981-18-76-(2,2,2-三氟乙氧基)烟腈

参考文献

ASTRAZENECA AB
Patent: WO2007/73303 A2, 2007 ;
Location in patent: Page/Page column 29 ;
WO 2007/073303 A2

33252-28-76-氯-3-氰基吡啶+

124-40-3二甲胺

154924-17-16-(二甲胺基)-3-氰基吡啶

参考文献

FORMA THERAPEUTICS, INC.; GENENTECH, INC.; BAIR, Kenneth W.; BAUMEISTER, Timm B.; BUCKMELTER, Alexandre J.; CLODFELTER, Karl H.; HAN, Bingsong; LIN, Jian; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; ZHENG, Xiaozhang; YUEN, Po-Wai
Patent: WO2012/31196 A1, 2012 ;
Location in patent: Page/Page column 235-236 ;
WO 2012/031196 A1

33252-28-76-氯-3-氰基吡啶

23100-12-16-氯烟醛

参考文献

Imperial Chemical Industries Limited
Patent: US4317913 A1, 1982 ;

33252-28-76-氯-3-氰基吡啶

3731-52-03-氨甲基吡啶+

23100-12-16-氯烟醛

参考文献

Tetrahedron Letters, , vol. 40, # 32 p. 5885 - 5888