双(1H-苯并三唑-5-胺)硫酸盐合成路线 （共 3 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran P=2378.9 Torr;
参考文献
Sanna; Paglietti
Farmaco, 1989 , vol. 44, # 6 p. 609 - 618
反应条件
1: With hydrogenchloride; sodium nitrite T=0°C; Diazotization; 2: With potassium iodide in water T=25°C; Iodination; 2 h; Further stages.;
参考文献
Wright; Gregory; Kesten; Boxer; Serpa; Meltzer; Wise; Espitia; Konkoy; Whittemore; Woodward
Journal of Medicinal Chemistry, 2000 , vol. 43, # 18 p. 3408 - 3419
反应条件
1: 5-Aminobenzotriazole With Sodium hydride in DMF (N,N-dimethyl-formamide)
T=20°C; 0.333333 h; Under N2;
2: di-tert-butyl dicarbonate in DMF (N,N-dimethyl-formamide)
2 h;
参考文献
Harris, Philip Anthony; McNutt JR., Robert Walton; Kuyper, Lee Frederick; Lackey, Karen Elizabeth; Peel, Michael Robert; Wood III, Edgar Raymond
Patent: US2003/225090 A1, 2003 ;
Location in patent: Page 24 ;
US 20030225090 A1
