2-(4-氯苯基)乙酸叔丁酯合成路线 （共 8 条）
反应条件
in toluene T=80°C; 18 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/122156 A1, 2007 ;
Location in patent: Page/Page column 90 ;
WO 2007/122156 A1
反应条件
in toluene T=80°C; 18 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/47336 A1, 2009 ;
Location in patent: Page/Page column 57 ;
WO 2009/047336 A1
反应条件
dicobalt octacarbonyl; water T=190°C; P=43957.6 - 46543.3 Torr; 24 h;
参考文献
Shim, Sang Chul; Antebi, Shlomo; Alper, Howard
Journal of Organic Chemistry, 1985 , vol. 50, # 1 p. 147 - 149
反应条件
in dichloromethane T=-10 - 20°C;
参考文献
MERCK SHARP andamp; DOHME CORP.; LIN, Songnian; STEVENSON, Christian, P.; PARMEE, Emma, R.; XU, Libo; LIAO, Xibin; METZGER, Edward; LIANG, Rui; ZHANG, Fengqi; STELMACH, John, E.
Patent: WO2010/30722 A1, 2010 ;
Location in patent: Page/Page column 80 ;
WO 2010/030722 A1
反应条件
[P(t-Bu)3Pd(μ-Br)]2 in tetrahydrofuran T=20°C; 12 h; Inert atmosphereSealed tube; Reagent/catalyst;
参考文献
Hama, Takuo; Ge, Shaozhong; Hartwig, John F.
Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8250 - 8266
反应条件
iron (III) acetylacetonate in tetrahydrofuran T=-78°C; 1 h;
参考文献
Jin, Masayoshi; Nakamura, Masaharu
Chemistry Letters, 2011 , vol. 40, # 9 p. 1012 - 1014
反应条件
bis-triphenylphosphine-palladium(II) chloride; diisobutylaluminium hydride in tetrahydrofuran; toluene 1.) 0 deg C, 5 min, 2.) room temperature, overnight;
参考文献
Orsini, F.; Pelizzoni, F.
Synthetic Communications, 1987 , vol. 17, # 12 p. 1389 - 1402
参考文献
Allen, Darin A.; Pham, Phuongly; Choong, Ingrid C.; Fahr, Bruce; Burdett, Matthew T.; Lew, Willard; DeLano, Warren L.; Gordon, Eric M.; Lam, Joni W.; O'Brien, Tom; Lee, Dennis
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 21 p. 3651 - 3655
