4,4,-二(4-氟苯)氯丁烷合成路线 (共 6 条)
反应条件
thionyl chloride; hydrogen; palladium in benzene
反应条件
sodium carbonate; potassium iodide in 4-hydroxymethyl-1,3-dioxolane T=80°C; 7 h;
参考文献
INSTITUT UNIVERSITARI DE CIENCIA I TECNOLOGIA
Patent: WO2008/80601 A2, 2008 ;
Location in patent: Page/Page column 10-11 ;
参考文献
Tai, Chih-Ho; Wu, Hsiao-Ching; Li, Wen-Ren
Organic Letters, 2004 , vol. 6, # 17 p. 2905 - 2908
反应条件
sodium iodide in acetone
Heating;
参考文献
Cumming, John G.; Cooper, Anne E.; Grime, Ken; Logan, Chris J.; McLaughlin, Sharon; Oldfield, John; Shaw, John S.; Tucker, Howard; Winter, Jon; Whittaker, David
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 5012 - 5015
反应条件
potassium carbonate; potassium iodide in acetonitrile
48 h; Heating / reflux;
参考文献
SHIONOGI and CO., LTD.; EURO-CELTIQUE S.A
Patent: WO2008/8398 A2, 2008 ;
Location in patent: Page/Page column 380 ;
反应条件
1: NaI / acetone / Heating
2: KOtBu / tetrahydrofuran / 20 °C
View Scheme
参考文献
Cumming, John G.; Cooper, Anne E.; Grime, Ken; Logan, Chris J.; McLaughlin, Sharon; Oldfield, John; Shaw, John S.; Tucker, Howard; Winter, Jon; Whittaker, David
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 5012 - 5015