2-(3-氯丙基)-2-(4-氟苯基)-1,3-二氧戊烷合成路线 (共 14 条)
反应条件
toluene-4-sulfonic acid in water; toluene 16 h; Inert atmosphereReflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 12 p. 3622 - 3626
反应条件
toluene-4-sulfonic acid in ethylene glycol; benzene
反应条件
In(OSO2CF3)3 in acetone T=100°C; 0.0833333 h; microwave irradiation;
参考文献
Gregg, Brian T.; Golden, Kathryn C.; Quinn, John F.
Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5890 - 5893
反应条件
1: various solvent(s) / 12 h / Heating 2: concd. HCl / methanol / 2 h / Heating View Scheme
参考文献
Cortizo; Santana; Ravina; Orallo; Fontenla; Castro; Calleja; De Ceballos
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2242 - 2247
反应条件
in various solvent(s) 12 h; Heating;
参考文献
Cortizo; Santana; Ravina; Orallo; Fontenla; Castro; Calleja; De Ceballos
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2242 - 2247
反应条件
1: K2CO3, KI / dimethylformamide / 17.5 h / 100 °C 2: 65 percent / conc. HCl / methanol / 6 h / Heating View Scheme
参考文献
Moerlein, Stephen M.; Stoecklin, Gerhard L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1319 - 1324
反应条件
1: 77.4 percent / xylene / 13 h / Heating 2: NaBH4 / 2.5 h 3: KOH, CS2 / ethanol / 3 h / Heating View Scheme
参考文献
Sato; Arimoto
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 719 - 722
反应条件
sodium carbonate; sodium iodide in N,N-dimethyl-formamide
T=80°C; 24 h;
参考文献
Metwally, Kamel A.; Dukat, Malgorzata; Egan, Christina T.; Smith, Carol; DuPre, Ann; Gauthier, Colleen B.; Herrick-Davis, Katharine; Teitler, Milt; Glennon, Richard A.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 5084 - 5093
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide
1.) room temp., overnight, 2.) reflux, 1 h;
参考文献
Sui; De Voss; DeCamp; Li; Craik; Ortiz De Montellano
Synthesis, 1993 , # 8 p. 803 - 808
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide
T=100°C; 17.5 h;
参考文献
Moerlein, Stephen M.; Stoecklin, Gerhard L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1319 - 1324