5-甲基-6-苯基-2H-吡嗪基-3-酮合成路线 （共 10 条）
反应条件
1: T=100 - 105°C; 2 h; 2: With ammonium hydroxide; hydrazine hydrate 2 h; Heating; Further stages.;
参考文献
Contreras; Parrot; Sippl; Rival; Wermuth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2707 - 2718
反应条件
bromine; acetic acid T=60 - 70°C; 3 h;
参考文献
Ravina, Enrique; Teran, Carmen; Santana, Lourdes; Garcia, Neftali; Estevez, Isabel
Heterocycles, 1990 , vol. 31, # 11 p. 1967 - 1974
反应条件
selenium(IV) oxide in ethanol 1 h; Heating;
参考文献
Ravina, Enrique; Teran, Carmen; Santana, Lourdes; Garcia, Neftali; Estevez, Isabel
Heterocycles, 1990 , vol. 31, # 11 p. 1967 - 1974
反应条件
hydrazine hydrate in acetic acid 3 h; Heating;
参考文献
Curzu; Pinna; Barlocco; Cignarella
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 205 - 208
反应条件
hydrazine hydrate in acetic acid 3 h; Heating;
参考文献
Curzu; Pinna; Barlocco; Cignarella
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 205 - 208
反应条件
acetic acid 3 h; Heating;
参考文献
Coates; McKillop
Synthesis, 1993 , # 3 p. 334 - 342
反应条件
1: 1.) 0.5 N NaOH; 2.) conc. HCl / 1.) water, 1 h, r.t; 2.) pH = 2, 12 h 2: hydrazine monohydrate / acetic acid / 3 h / Heating View Scheme
参考文献
Barlocco; Martini; Pinna; Curzu; Sala; Germini
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 8 p. 585 - 594
反应条件
hydrazine hydrate 3 h; Heating;
参考文献
Curzu; Pinna; Barlocco; Cignarella
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 205 - 208
反应条件
ammonium hydroxide; hydrazine hydrate 1) 110 deg C, 2) water, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Coates; McKillop
Synthesis, 1993 , # 3 p. 334 - 342
反应条件
trichlorophosphate
T=80°C; 4 h;
参考文献
Contreras; Parrot; Sippl; Rival; Wermuth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2707 - 2718
