hydrogen; lt;Rh(R-PROPHOS)(NBD)gt;PF6 in tetrahydrofuran 1.5 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

[(S)-BINAPRuCl(benzene)]Cl; hydrogen in methanol T=20 - 50°C; P=3750.38 Torr; 12 h; AutoclaveInert atmosphere; Overall yield = 82 percent; enantioselective reaction;

1: 59 percent / H2O / acetone 2: H2 / <Rh(R-PROPHOS)(NBD)>PF6 / tetrahydrofuran / 1.5 h View Scheme

1: 40 percent / acetic anhydride / Heating 2: 59 percent / H2O / acetone 3: H2 / <Rh(R-PROPHOS)(NBD)>PF6 / tetrahydrofuran / 1.5 h View Scheme

1: sodium acetate; acetic anhydride / 3.75 h / 40 - 135 °C 2: water; acetone / 6 h / |Reflux 3: [(S)-BINAPRuCl(benzene)]Cl; hydrogen / methanol / 12 h / 20 - 50 °C / 3750.38 Torr / |Autoclave; |Inert atmosphere View Scheme