1H-咪唑-4,5-二甲酸二甲酯合成路线 (共 22 条)
反应条件
sulfuric acid 24 h; Reflux;
参考文献
Myles, Lauren; Gore, Rohitkumar G.; Gathergood, Nicholas; Connon, Stephen J.
Green Chemistry, 2013 , vol. 15, # 10 p. 2740 - 2746
反应条件
triethylamine in dichloromethane 0.5 h; Heating;
参考文献
Ivanov, E. I.; Bogatskii, A. V.; Abramovich, A. E.
Doklady Chemistry, 1980 , vol. 255, p. 516 - 518
Dokl. Akad. Nauk SSSR Ser. Khim., 1980 , vol. 255, # 2 p. 359 - 361
参考文献
Schering Corporation
Patent: US4587241 A1, 1986 ;
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Kavadias; Luh; Saintonge
Canadian Journal of Chemistry, 1982 , vol. 60, # 6 p. 723 - 729
反应条件
1: N2H4 2: N2H4+H2O 3: N,N-dimethyl-aniline; POCl3 View Scheme
参考文献
Castle; Seese
Journal of Organic Chemistry, 1958 , vol. 23, p. 1534,1536
反应条件
1: N2H4 2: N2H4+H2O 3: POCl3 View Scheme
参考文献
Castle; Seese
Journal of Organic Chemistry, 1958 , vol. 23, p. 1534,1536
反应条件
1: 93 percent / triethylamine / dimethylformamide / 4 h / Ambient temperature 2: sodium borohydride, lithium bromide / bis-(2-methoxy-ethyl) ether / 1.)25 degC, 7 h, 2.) 0 degC overnight, 3.) 25 degC 5 h 3: 90 percent / ethanol; acetic acid / 0.75 h / Heating View Scheme
参考文献
Kavadias; Luh; Saintonge
Canadian Journal of Chemistry, 1982 , vol. 60, # 6 p. 723 - 729
参考文献
Baxter; Spring
Journal of the Chemical Society, 1954 , p. 232
Full Text Show Details
Segura Ferns et al.
An. Inst. Farmacol. espan., 1958 , vol. 7, p. 215,227, 228, 229
Full Text Show Details
Merck and Co. Inc.
Patent: US2872371 , 1957 ;
反应条件
bromine; potassium carbonate in dichloromethane; acetonitrile T=20°C;
参考文献
Eckhardt, Matthias; Hauel, Norbert; Langkopf, Elke; Himmelsbach, Frank
Tetrahedron Letters, 2008 , vol. 49, # 12 p. 1931 - 1934
参考文献
Piotrovskii, L. B.; Dumpis, M. A.; Shabanov, P. D.
Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 7 p. 460 - 463
Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 7 p. 799 - 802