Boc-beta-丙氨酸合成路线 （共 48 条）
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C; Product distribution / selectivity;
参考文献
SHANGHAI HENGRUI PHARMACEUTICAL CO. LTD.
Patent: WO2007/85188 A1, 2007 ;
Location in patent: Page/Page column 107; 112 ;
WO 2007/085188 A1
反应条件
potassium carbonate in water; N,N-dimethyl-formamide
T=70°C; 16 h;
参考文献
McCubbin, J. Adam; Maddess, Matthew L.; Lautens, Mark
Organic Letters, 2006 , vol. 8, # 14 p. 2993 - 2996
反应条件
4-methyl-morpholine; 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride
参考文献
TOKUYAMA CORPORATION
Patent: EP1178043 A1, 2002 ;
Location in patent: Page 31, 32 ;
反应条件
1: TEA / tetrahydrofuran / 0 °C
2: tetrahydrofuran / 0 °C
View Scheme
参考文献
Shin, Kye Jung; Yoo, Kyung Ho; Kim, Dong Jin; Park, Sang Woo; Ko, Bong Suck; Lee, Sang Joo; Huh, Jae Doo; Park, Seung Yong
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 13 p. 1607 - 1612
反应条件
hydrazine in ethanol
24 h; Heating / reflux;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2006/62224 A1, 2006 ;
Location in patent: Page/Page column 81 ;
反应条件
phosphorus tribromide in dichloromethane
T=0°C; 4 h;
参考文献
McKiernan; Huck; Fehrentz; Roumestant; Viallefont; Martinez
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6541 - 6544
反应条件
pyridine; oxalyl dichloride in tetrahydrofuran; DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 1 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1466904 A1, 2004 ;
Location in patent: Page 39-40 ;
反应条件
1: N-tert-butoxycarbonyl-β-alanine With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate in DMF (N,N-dimethyl-formamide)
T=20°C; 0.25 h;
2: 2-methyl-quinoline-4,6-diamine With n-ethyl morpholine in DMF (N,N-dimethyl-formamide)
T=20°C; 24 h;
参考文献
Aventis Pharma Deutschland GmbH; AJINOMOTO CO., INC., Pharmaceutical Company
Patent: EP1369420 A1, 2003 ;
Location in patent: Page 12 ;
