2-异丙基-3,3-二甲基丁酸合成路线 （共 11 条）
反应条件
hydrogenchloride in 1,4-dioxane Heating;
参考文献
Schaumann, Ernst
Chemische Berichte, 1982 , vol. 115, p. 2755 - 2765
反应条件
1: dilithiated tert-butylacetic acid With N,N'-dimethyl-N,N'-propyleneurea in tetrahydrofuran T=5°C; 0.5 h; 2: 2-iodo-propane in tetrahydrofuran T=20°C; 2 h;
参考文献
Kaufmann, Dan; Bialer, Meir; Shimshoni, Jakob Avi; Devor, Marshall; Yagen, Boris
Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7236 - 7248
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide 1.) 0 deg C, THF; 2.) 0 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Hen, Naama; Bialer, Meir; Wlodarczyk, Bogdan; Finnell, Richard H.; Yagen, Boris
Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 4177 - 4186
反应条件
sulfuric acid; sodium nitrite
参考文献
Tsai et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 2530
反应条件
1: sodium ethylate; ethanol 2: potassium hydroxide 3: sodium nitrite; aqueous sulfuric acid View Scheme
参考文献
Tsai et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 2530
反应条件
1: potassium hydroxide 2: sodium nitrite; aqueous sulfuric acid View Scheme
参考文献
Tsai et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 2530
反应条件
NOBF4 in acetonitrile
参考文献
Olah,G.A.; Olah,J.A.
Journal of Organic Chemistry, 1965 , vol. 30, p. 2386 - 2387
反应条件
1: 61 percent / NaH / toluene / 4 h / Heating 2: 34 percent / KNH2 / liquid ammonia 3: 92 percent / HCl / dioxane / Heating View Scheme
参考文献
Schaumann, Ernst
Chemische Berichte, 1982 , vol. 115, p. 2755 - 2765
反应条件
1: 34 percent / KNH2 / liquid ammonia 2: 92 percent / HCl / dioxane / Heating View Scheme
参考文献
Schaumann, Ernst
Chemische Berichte, 1982 , vol. 115, p. 2755 - 2765
反应条件
boron trifluoride; water; acetic acid P=100 Torr;
参考文献
Pirozhkov,S.D. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1976 , vol. 25, p. 1264 - 1267
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1976 , vol. 25, # 6 p. 1314 - 1317
