1-三苯甲基咪唑-4-甲醛合成路线 （共 31 条）
反应条件
sodium hydroxide; silver(l) oxide in water
T=55°C; 15 h;
参考文献
Hunt, John T.; Lee, Ving G.; Leftheris, Katerina; Seizinger, Bernd; Carboni, Joan; et al.
J. Med. Chem., 1996 , vol. 39, # 2 p. 353 - 358
反应条件
iodine; magnesium
1.) THF, reflux, 1 h, 2.) r.t., THF, 1.5 h; Yield given. Multistep reaction;
参考文献
Cordi, Alex A.; Persigand, Thierry; Lecouve, Jean-Pierre
Synthetic Communications, 1996 , vol. 26, # 8 p. 1585 - 1593
反应条件
1: 1.) magnesium, iodine / 1.) THF, reflux, 1 h, 2.) r.t., THF, 1.5 h
2: 90 percent / MnO2 / dioxane / 5 h / Heating
3: 95 percent / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Cordi, Alex A.; Persigand, Thierry; Lecouve, Jean-Pierre
Synthetic Communications, 1996 , vol. 26, # 8 p. 1585 - 1593
反应条件
sodium iodide in dichloromethane
24 h; Heating / reflux;
参考文献
Perez, Michel; Lamothe, Marie; Hill, Bridget; Etievant, Chantal
Patent: US2004/204417 A1, 2004 ;
Location in patent: Page 15 ;
US 20040204417 A1
反应条件
in acetonitrile
T=20 - 60°C; Inert atmosphere;
参考文献
Suryadevara, Praveen Kumar; Olepu, Srinivas; Lockman, Jeffrey W.; Ohkanda, Junko; Karimi, Mandana; Verlinde, Christophe L. M. J.; Kraus, James M.; Schoepe, Jan; Van Voorhis, Wesley C.; Hamilton, Andrew D.; Buckner, Frederick S.; Gelb, Michael H.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 12 p. 3703 - 3715
反应条件
in acetonitrile
T=20 - 60°C; Inert atmosphere;
参考文献
Suryadevara, Praveen Kumar; Olepu, Srinivas; Lockman, Jeffrey W.; Ohkanda, Junko; Karimi, Mandana; Verlinde, Christophe L. M. J.; Kraus, James M.; Schoepe, Jan; Van Voorhis, Wesley C.; Hamilton, Andrew D.; Buckner, Frederick S.; Gelb, Michael H.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 12 p. 3703 - 3715
反应条件
in acetonitrile
T=20 - 60°C; Inert atmosphere;
参考文献
Suryadevara, Praveen Kumar; Olepu, Srinivas; Lockman, Jeffrey W.; Ohkanda, Junko; Karimi, Mandana; Verlinde, Christophe L. M. J.; Kraus, James M.; Schoepe, Jan; Van Voorhis, Wesley C.; Hamilton, Andrew D.; Buckner, Frederick S.; Gelb, Michael H.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 12 p. 3703 - 3715
反应条件
in acetonitrile
T=60°C;
参考文献
Ohkanda; Lockman; Kothare; Qian; Blaskovich; Sebti; Hamilton
Journal of Medicinal Chemistry, 2002 , vol. 45, # 1 p. 177 - 188
反应条件
1.1: n-butyllithium; Di-n-butylmagnesium / hexane; tetrahydrofuran / 1.5 h / -11 - 20 °C / Inert atmosphere
1.2: 7.5 h / -11 °C
2.1: manganese(IV) oxide / isobutyramide / 60 h / 25 °C / Inert atmosphere
3.1: pyridine; cinchonine / tetrahydrofuran / 1.75 h / -25 °C / Inert atmosphere
4.1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 8.5 h / -7 - 5 °C
4.2: 5 °C
View Scheme
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; KAWABATA, Yoichi; SAWAI, Yasuhiro; KANNO, Kazuaki; SAWADA, Naotaka
Patent: WO2012/173280 A1, 2012 ;
反应条件
in tetrahydrofuran; diethyl ether
Grignard reaction; 1 h;
参考文献
Matsunaga, Nobuyuki; Kaku, Tomohiro; Itoh, Fumio; Tanaka, Toshimasa; Hara, Takahito; Miki, Hiroshi; Iwasaki, Masahiko; Aono, Tetsuya; Yamaoka, Masuo; Kusaka, Masami; Tasaka, Akihiro
Bioorganic and medicinal chemistry, 2004 , vol. 12, # 9 p. 2251 - 2273
