alpha-叔丁氧羰基-L-苯丙氨酰-L-亮氨酸合成路线 （共 14 条）
反应条件
sodium hydroxide in methanol 1 h;
参考文献
Patel; Rielly-Gauvin; Ryono; Free; Smith; Petrillo Jr.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2431 - 2447
反应条件
sodium hydroxide; sodium hydrogencarbonate in N,N-dimethyl-formamide T=-5°C;
参考文献
Bobrova, Irina; Abissova, Natalia; Mishlakova, Natalia; Rozentals, Guntis; Chipens, Gunar
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 4 p. 255 - 266
反应条件
1: 70 percent / N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide*HCl; N-hydroxybenzotriazole; N-methylmorpholine / dimethylformamide / 12 h / 20 °C 2: aq. NaOH / tetrahydrofuran / 10 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 4 p. 1102 - 1106
反应条件
1: DCC / dimethylformamide / 20 °C 2: aq. NaOH / methanol / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 4 p. 661 - 665
反应条件
N-ethyl-N,N-diisopropylamine in N-methyl-acetamide; di-isopropyl ether; ethyl acetate
参考文献
US4981843 A1, ;
US 4981843 A
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran
反应条件
magnesium; acetic acid in methanol; N,N-dimethyl-formamide T=20°C; 1.66667 h;
参考文献
Organic Letters, , vol. 7, # 9 p. 1723 - 1724
反应条件
1: 89 percent / SOCl2 / 5 h / 20 °C 2: 70 percent / N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide*HCl; N-hydroxybenzotriazole; N-methylmorpholine / dimethylformamide / 12 h / 20 °C 3: aq. NaOH / tetrahydrofuran / 10 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 4 p. 1102 - 1106
反应条件
1.1: isobutyl chloroformate; Et3N / CH2Cl2 / 0.17 h / 0 °C 1.2: Et3N / CH2Cl2 / 20 °C 2.1: LiOH / H2O; methanol / 2 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 31 p. 5207 - 5210
反应条件
1: acetic acid; Mg / methanol; dimethylformamide / 75 h / 20 °C 2: 87 percent / 1-hydroxybenzotriazole; dicyclohexylcarbodiimide / dimethylformamide / 25 °C 3: 92 percent / lithium hydroxide monohydrate / methanol; H2O / 2 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 9 p. 1723 - 1724
