10-脱乙酰基巴卡丁 III合成路线 （共 66 条）
反应条件
sodium hydrogencarbonate in methanol; water 5 h; Ambient temperature; Further byproducts given;
参考文献
Journal of Organic Chemistry, , vol. 46, # 7 p. 1469 - 1474
反应条件
Marchantia polymorpha; BG-11 medium T=25°C; Further byproducts.;
参考文献
Chemistry Letters, , vol. 37, # 3 p. 362 - 363
反应条件
sodium hydrogencarbonate in methanol; water 5 h; Ambient temperatureother base; Further byproducts given;
参考文献
Journal of Organic Chemistry, , vol. 46, # 7 p. 1469 - 1474
反应条件
Enterobacter sp. CGMCC 2487 Microbiological reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 68, # 3-4 p. 250 - 255
反应条件
1: With triethylamine; copper dichloride in ethanol; ethyl acetate T=-13 - -8°C; 2: With ammonia; ammonium chloride in ethanol; water; ethyl acetate Product distribution / selectivity;
参考文献
TAPESTRY PHARMACEUTICALS, INC.
Patent: WO2007/75870 A2, 2007 ;
Location in patent: Page/Page column 31-32 ;
反应条件
copper diacetate; air in methanol 72 h;
参考文献
Appendino, Giovanni; Noncovich, Alain; Bettoni, Piergiorgio; Dambruoso, Paolo; Sterner, Olov; Fontana, Gabriele; Bombardelli, Ezio
European Journal of Organic Chemistry, 2003 , # 22 p. 4422 - 4431
反应条件
fungus Curvularia lunata block strain 198-ICRM culture in dimethyl sulfoxide Microbiological reactionEnzymatic reaction;
参考文献
Arnone, Alberto; Bava, Adriana; Fronza, Giovanni; Nasini, Gianluca
Journal of Natural Products, 2009 , vol. 72, # 11 p. 2000 - 2004
反应条件
1: 71 percent / pyridine / 0.5 h / 80 °C 2: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 10-deacetyl baccatin III With lithium hexamethyldisilazane in tetrahydrofuran T=-72°C; 0.666667 h; Inert atmosphere; 2: methyl trifluoromethanesulfonate in tetrahydrofuran T=-72°C; 4.08333 h; Inert atmosphere;
参考文献
Jing, Yun-Rong; Zhou, Wei; Li, Wan-Liang; Zhao, Lin-Xiang; Wang, Yong-Feng
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 194 - 203
反应条件
potassium hydride in tetrahydrofuran T=-20 - 20°C; 8 h;
参考文献
YUNG SHIN PHARM. IND. CO., LTD.; KUNG, Liang-Rern; HUNG, Yi-Ting; FANG, Tung-Shen; CHANG, Po-Wei; HUANG, Tsang-Miao
Patent: WO2014/22237 A1, 2014 ;
Location in patent: Page/Page column 6 ;
