10-脱乙酰基巴卡丁 III合成路线 （共 66 条）
反应条件
sodium periodate in tetrahydrofuran; water T=30 - 40°C; 144 h;
参考文献
Wang, Mijuan; Li, Chun; Yin, Dali; Liang, Xiao-Tian
Tetrahedron Letters, 2002 , vol. 43, # 48 p. 8727 - 8729
反应条件
water; hydrazine in ethanol T=20°C; 2 h; Product distribution / selectivity;
参考文献
6570763 CANADA INC.
Patent: WO2007/101335 A1, 2007 ;
Location in patent: Page/Page column 9-10 ;
反应条件
water; hydrazine in ethanol T=20°C; 2 h; Product distribution / selectivity;
参考文献
6570763 CANADA INC.
Patent: WO2007/101335 A1, 2007 ;
Location in patent: Page/Page column 9 ;
反应条件
hydrazine hydrate in ethanol 2 h; Ambient temperature;
参考文献
Datta; Hepperle; Georg
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 761 - 763
反应条件
hydrazine hydrate in ethanol 2 h; Ambient temperature;
参考文献
Datta; Hepperle; Georg
Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 761 - 763
参考文献
NaPro BioTherapeutics, Inc.
Patent: US5256801 A1, 1993 ;
反应条件
1: 91 percent / tetrahydrofuran / -78 °C 2: 94 percent / HCl; H2O; NaI / dioxane 3: 92 percent / pyridine / CH2Cl2 / -30 °C 4: Dess-Martin periodinane / CH2Cl2 5: Et3N 6: 89 percent / ZnCl2 / tetrahydrofuran / -78 °C 7: N,N-diisopropylethylamine / 55 °C 8: NH4F / methanol / 20 °C 9: tetrahydrofuran / -78 °C 10: imidazole / CHCl3 11: 92 percent / pyridine / CH2Cl2 12: 76 percent / KCN / ethanol / 0 °C 13: 95 percent / (i-Pr)2NEt / toluene / 110 °C 14: 89 percent / DMAP 15: 96 percent / TASF / tetrahydrofuran / 0 °C 16: tetrahydrofuran / -78 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 11 p. 2757 - 2758
反应条件
1: 92 percent / pyridine / CH2Cl2 / -30 °C 2: Dess-Martin periodinane / CH2Cl2 3: Et3N 4: 89 percent / ZnCl2 / tetrahydrofuran / -78 °C 5: N,N-diisopropylethylamine / 55 °C 6: NH4F / methanol / 20 °C 7: tetrahydrofuran / -78 °C 8: imidazole / CHCl3 9: 92 percent / pyridine / CH2Cl2 10: 76 percent / KCN / ethanol / 0 °C 11: 95 percent / (i-Pr)2NEt / toluene / 110 °C 12: 89 percent / DMAP 13: 96 percent / TASF / tetrahydrofuran / 0 °C 14: tetrahydrofuran / -78 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 11 p. 2757 - 2758
反应条件
1: Dess-Martin periodinane / CH2Cl2 2: Et3N 3: 89 percent / ZnCl2 / tetrahydrofuran / -78 °C 4: N,N-diisopropylethylamine / 55 °C 5: NH4F / methanol / 20 °C 6: tetrahydrofuran / -78 °C 7: imidazole / CHCl3 8: 92 percent / pyridine / CH2Cl2 9: 76 percent / KCN / ethanol / 0 °C 10: 95 percent / (i-Pr)2NEt / toluene / 110 °C 11: 89 percent / DMAP 12: 96 percent / TASF / tetrahydrofuran / 0 °C 13: tetrahydrofuran / -78 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 11 p. 2757 - 2758
反应条件
1: 89 percent / ZnCl2 / tetrahydrofuran / -78 °C 2: N,N-diisopropylethylamine / 55 °C 3: NH4F / methanol / 20 °C 4: tetrahydrofuran / -78 °C 5: imidazole / CHCl3 6: 92 percent / pyridine / CH2Cl2 7: 76 percent / KCN / ethanol / 0 °C 8: 95 percent / (i-Pr)2NEt / toluene / 110 °C 9: 89 percent / DMAP 10: 96 percent / TASF / tetrahydrofuran / 0 °C 11: tetrahydrofuran / -78 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 11 p. 2757 - 2758
