N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯合成路线 （共 130 条）
反应条件
1: 83 percent / thallium trinitrate trihydrate / 27 °C 2: triphenyphosphine, hydrazoic acid, diethyl azodicarboxylate / benzene / 1 h / Ambient temperature 3: triphenylphosphine, water / tetrahydrofuran / 15 h / 60 °C 4: DMAP / CH2Cl2 / 1 h / Ambient temperature 5: 78 percent / H2, 10percent HCl / 10percent Pd/C / ethanol / 1 h / 60 °C View Scheme
参考文献
Tetrahedron, , vol. 49, # 37 p. 8323 - 8336
反应条件
1: H2 / Pd/C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 115, # 3 p. 1151 - 1152
反应条件
caesium carbonate in tetrahydrofuran T=20°C; 1.5 h;
参考文献
Afon'Kin; Kostrikin; Shumeiko; Popov; Matveev; Matvienko; Zabudkin
Russian Chemical Bulletin, 2012 , vol. 61, # 11 p. 2149 - 2162
Izv. Akad. Nauk, Ser. Khim., 2012 , # 11 p. 2132 - 2145,14
反应条件
lithium iodide in methanol 10 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 49, # 14 p. 2805 - 2828
反应条件
lithium iodide in methanol 14 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 49, # 14 p. 2805 - 2828
反应条件
1.1: Et3N / LDH-PdOsW / 16 h / 70 °C 1.2: 90 percent / aq. H2O2; (DHQ)2PHAL; N-methylmorpholine / LDH-PdOsW / 2-methyl-propan-2-ol / 1 h / 20 °C 2.1: 96 percent / HBr / 0.5 h / 45 °C 3.1: NaN3 / dimethylformamide / 12 h / 50 °C 4.1: NaOAc / methanol / 12 h 5.1: Et3N; DMAP / ethyl acetate / 4 h / 20 °C 5.2: 92 percent / H2 / Pd/C / ethyl acetate; methanol / 48 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 5 p. 1736 - 1746
反应条件
1.1: 96 percent / HBr / 0.5 h / 45 °C 2.1: NaN3 / dimethylformamide / 12 h / 50 °C 3.1: NaOAc / methanol / 12 h 4.1: Et3N; DMAP / ethyl acetate / 4 h / 20 °C 4.2: 92 percent / H2 / Pd/C / ethyl acetate; methanol / 48 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 5 p. 1736 - 1746
反应条件
1.1: NaOAc / methanol / 12 h 2.1: Et3N; DMAP / ethyl acetate / 4 h / 20 °C 2.2: 92 percent / H2 / Pd/C / ethyl acetate; methanol / 48 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 5 p. 1736 - 1746
反应条件
1.1: NaN3 / dimethylformamide / 12 h / 50 °C 2.1: NaOAc / methanol / 12 h 3.1: Et3N; DMAP / ethyl acetate / 4 h / 20 °C 3.2: 92 percent / H2 / Pd/C / ethyl acetate; methanol / 48 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 5 p. 1736 - 1746
反应条件
1: lipase Pseudomonas cepacia / Ambient temperature 2: 89 percent / HBr 3: NaN3 / dimethylformamide 4: AcONa / methanol 5: 1.) Et3N; 2.) H2 / 2.) Pd/C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 15 p. 2163 - 2166
