N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯合成路线 （共 130 条）
反应条件
1: 99 percent / L-Selectride / tetrahydrofuran / 4 h / 0 °C 2: 99 percent / Deoxo-Fluor(R) / CH2Cl2 / 0.5 h / -20 °C 3: 94 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h 4: pyridinium chlorochromate / dimethylformamide / 2 h 5: dimethylformamide; diethyl ether 6: 85 percent / HCl / methanol / 5 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 941 - 949
反应条件
1: 99 percent / Deoxo-Fluor(R) / CH2Cl2 / 0.5 h / -20 °C 2: 94 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h 3: pyridinium chlorochromate / dimethylformamide / 2 h 4: dimethylformamide; diethyl ether 5: 85 percent / HCl / methanol / 5 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 941 - 949
反应条件
1.1: Et3N / CH2Cl2 / 20 °C 2.1: tetrahydrofuran / -78 °C 3.1: NaH / tetrahydrofuran / 20 °C 4.1: O3; NaOH / CH2Cl2 / -78 °C 5.1: HCl / methanol / 20 °C 6.1: 75 percent / Zn(BH4)2 / tetrahydrofuran / -78 °C 7.1: NaHCO3 / methanol / 0 °C 8.1: SOCl2 / CH2Cl2 / Heating 9.1: HCl / H2O; methanol / Heating 9.2: NaHCO3 / H2O; methanol / 50 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 23 p. 3639 - 3641
反应条件
1.1: tetrahydrofuran / -78 °C 2.1: NaH / tetrahydrofuran / 20 °C 3.1: O3; NaOH / CH2Cl2 / -78 °C 4.1: HCl / methanol / 20 °C 5.1: 75 percent / Zn(BH4)2 / tetrahydrofuran / -78 °C 6.1: NaHCO3 / methanol / 0 °C 7.1: SOCl2 / CH2Cl2 / Heating 8.1: HCl / H2O; methanol / Heating 8.2: NaHCO3 / H2O; methanol / 50 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 23 p. 3639 - 3641
反应条件
1.1: HCl / methanol / 20 °C 2.1: 75 percent / Zn(BH4)2 / tetrahydrofuran / -78 °C 3.1: NaHCO3 / methanol / 0 °C 4.1: SOCl2 / CH2Cl2 / Heating 5.1: HCl / H2O; methanol / Heating 5.2: NaHCO3 / H2O; methanol / 50 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 23 p. 3639 - 3641
反应条件
1.1: O3; NaOH / CH2Cl2 / -78 °C 2.1: HCl / methanol / 20 °C 3.1: 75 percent / Zn(BH4)2 / tetrahydrofuran / -78 °C 4.1: NaHCO3 / methanol / 0 °C 5.1: SOCl2 / CH2Cl2 / Heating 6.1: HCl / H2O; methanol / Heating 6.2: NaHCO3 / H2O; methanol / 50 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 23 p. 3639 - 3641
反应条件
1.1: NaH / tetrahydrofuran / 20 °C 2.1: O3; NaOH / CH2Cl2 / -78 °C 3.1: HCl / methanol / 20 °C 4.1: 75 percent / Zn(BH4)2 / tetrahydrofuran / -78 °C 5.1: NaHCO3 / methanol / 0 °C 6.1: SOCl2 / CH2Cl2 / Heating 7.1: HCl / H2O; methanol / Heating 7.2: NaHCO3 / H2O; methanol / 50 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 23 p. 3639 - 3641
反应条件
1: HCl 2: NaHCO3 / ethyl acetate View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2693 - 2697
反应条件
1: aq. HCl / 2 h / Heating 2: HCl 3: NaHCO3 / ethyl acetate View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2693 - 2697
反应条件
1: 66 percent / DEAD; PPh3 / benzene / 12 h / 20 °C 2: 90 percent / 1N aq. HCl / methanol / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 22 p. 4485 - 4497
