N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯合成路线 （共 130 条）
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; triethylamine in ethyl acetate T=20°C; 4 h; 2: With hydrogen; palladium on activated charcoal in methanol; ethyl acetate 48 h; Further stages.;
参考文献
Council of Scientific and Industrial Research
Patent: US6706901 B1, 2004 ;
Location in patent: Page column 5 ;
反应条件
palladium on activated charcoal; hydrogen in methanol P=4654.46 Torr;
参考文献
CORDOVA, Armando; DZIEDZIC, Pawel; KULLBERG, Martin
Patent: WO2010/62239 A1, 2010 ;
Location in patent: Page/Page column 19 ;
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Bonini; Righi
Journal of the Chemical Society - Series Chemical Communications, 1994 , # 24 p. 2767 - 2768
反应条件
hydrogenchloride in methanol 2 h; Heating;
参考文献
Hamamoto, Hiromi; Mamedov, Vakhid A.; Kitamoto, Makiko; Hayashi, Nobuyuki; Tsuboi, Sadao
Tetrahedron Asymmetry, 2000 , vol. 11, # 22 p. 4485 - 4497
反应条件
in tetrahydrofuran; diethyl ether
参考文献
Washington State University Research Foundation
Patent: US2003/108891 A1, 2003 ;
Title/Abstract Full Text Show Details
Washington State University Research Foundation
Patent: US2004/5562 A9, 2004 ;
反应条件
sodium methylate in methanol T=20°C; 1 h;
参考文献
Aggarwal, Varinder K.; Vasse, Jean-Luc
Organic Letters, 2003 , vol. 5, # 21 p. 3987 - 3990
反应条件
1: methanol; (2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester With hydrogenchloride Addition; 20 h; Heating; 2: benzyl chloride With triethylamine in dichloromethane T=0 - 20°C; Substitution; 2 h; Further stages.;
参考文献
Lee, Sang-Hyeup; Yoon, Juyoung; Nakamura, Kensuke; Lee, Yoon-Sik
Organic Letters, 2000 , vol. 2, # 9 p. 1243 - 1246
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine; palladium on charcoal in methanol; dichloromethane; ethyl acetate
反应条件
silver trifluoroacetate Ambient temperature;
参考文献
Mukaiyama, Teruaki; Shiina, Isamu; Iwadare, Hayato; Saitoh, Masahiro; Nishimura, Toshihiro; Ohkawa, Naoto; Sakoh, Hiroki; Nishimura, Koji; Tani, Yu-Ichirou; Hasegawa, Masatoshi; Yamada, Koji; Saitoh, Katsuyuki
Chemistry - A European Journal, 1999 , vol. 5, # 1 p. 121 - 161
反应条件
1: methanol; (2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester With hydrogenchloride 20 h; Heating; 2: benzoyl chloride With triethylamine in dichloromethane T=0 - 20°C;
参考文献
Lee, Sang-Hyeup; Qi, Xin; Yoon, Juyoung; Nakamura, Kensuke; Lee, Yoon-Sik
Tetrahedron, 2002 , vol. 58, # 14 p. 2777 - 2787
