2,4,6,8-四氯嘧啶并[5,4-d]嘧啶合成路线 (共 13 条)
反应条件
1.1: aq. ammonium chloride / 1 h / 140 - 210 °C 1.2: 73 percent / aq. NaOH / Heating 2.1: 51 percent / POCl3; PCl5 / 15 h / Heating View Scheme
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 1 p. 108 - 115
参考文献
Basha, Anwer; Ratajczyk, James D.; Dyer, Richard D.; Young, Patrick; Carter, George W.; Brooks, Clint D.W.
Medicinal Chemistry Research, 1996 , vol. 6, # 1 p. 61 - 67
反应条件
ethanol anschliessendes Erhitzen unter Zusatz von wenig CuSO4 auf 200grad;
参考文献
Basha, Anwer; Ratajczyk, James D.; Dyer, Richard D.; Young, Patrick; Carter, George W.; Brooks, Clint D.W.
Medicinal Chemistry Research, 1996 , vol. 6, # 1 p. 61 - 67
反应条件
in tetrahydrofuran T=25°C;
参考文献
Curtin, Nicola J.; Barlow, Hannah C.; Bowman, Karen J.; Calvert, A. Hilary; Davison, Richard; Golding, Bernard T.; Huang, Bing; Loughlin, Peter J.; Newell, David R.; Smith, Peter G.; Griffin, Roger J.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4905 - 4922
反应条件
1: tetrahydrofuran / 0.33 h / 0 - 5 °C 2: 274 mg / dimethylsulfoxide / 6 h / 160 °C View Scheme
参考文献
Lin, Wenwei; Buolamwini, John K.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 16 p. 3906 - 3920
反应条件
1: 74 percent / tetrahydrofuran / 25 °C 2: 62 percent / 100 - 150 °C View Scheme
参考文献
Curtin, Nicola J.; Barlow, Hannah C.; Bowman, Karen J.; Calvert, A. Hilary; Davison, Richard; Golding, Bernard T.; Huang, Bing; Loughlin, Peter J.; Newell, David R.; Smith, Peter G.; Griffin, Roger J.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4905 - 4922
参考文献
Basha, Anwer; Ratajczyk, James D.; Dyer, Richard D.; Young, Patrick; Carter, George W.; Brooks, Clint D.W.
Medicinal Chemistry Research, 1996 , vol. 6, # 1 p. 61 - 67
反应条件
in tetrahydrofuran
T=25°C;
参考文献
Curtin, Nicola J.; Barlow, Hannah C.; Bowman, Karen J.; Calvert, A. Hilary; Davison, Richard; Golding, Bernard T.; Huang, Bing; Loughlin, Peter J.; Newell, David R.; Smith, Peter G.; Griffin, Roger J.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4905 - 4922
反应条件
1,4-dioxane; ammonia
参考文献
Lin, Wenwei; Buolamwini, John K.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 16 p. 3906 - 3920
反应条件
in tetrahydrofuran
T=0 - 5°C;
参考文献
Lin, Wenwei; Buolamwini, John K.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 16 p. 3906 - 3920