sodium carbonate; benzenesulfonyl chloride in water; acetone T=0°C;

ammonium hydroxide; hydrogen; palladium on activated charcoal in water 1) 70 deg C, 500 psig, 25.5 h; 2) 160 deg C, 500 psig, 4 h; further conditions and reagents;

1: 63 percent Chromat. / 27 °C / microbial hydrolysis by Acidovorax facilis 72W, ATCC 55746; pH 7.0 (potassium phosphate buffer); further microbial catalyst: A. facilis 72 PF-15 2: 59 percent / conc. NH4OH, H2 / Raney nickel / H2O / 3 h / 160 °C / 25857.4 Torr View Scheme

Hg(II)-EDTA in dichloromethane 18 h; HeatingpH 8.0; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

1: hydroxylamine hydrochloride; sodium carbonate / water; methanol / 5 h / 20 °C 2: benzenesulfonyl chloride; sodium carbonate / water; acetone / 0 °C View Scheme