3-溴-5-氯苯并[b]噻吩合成路线 （共 8 条）
反应条件
1: With bromine; sodium acetate in dichloromethane T=0°C; 0.0833333 h; 2: With PPA in dichloromethane; chlorobenzene 0.0833333 h; Heating / reflux;
参考文献
Kahraman, Mehmet; Borchardt, Allen J.; Cook, Travis G.; Davis, Robert L.; Gardiner, Elizabeth M.M.; Malecha, James W.; Noble, Stewart A.; Prins, Thomas J.
Patent: US2008/21026 A1, 2008 ;
Location in patent: Page/Page column 17; 27 ;
US 20080021026 A1
反应条件
1: 22 percent / 90percent aq. nitric acid / acetic acid; acetic anhydride / 1.5 h / 20 °C 2: 80 percent / 0.25 h / Heating View Scheme
参考文献
Guerrera; Salerno; Sarva; Siracusa; Lamartina; Caruso; Cutuli
Farmaco, 1992 , vol. 47, # 9 p. 1149 - 1160
反应条件
1: 22 percent / 90percent aq. nitric acid / acetic acid; acetic anhydride / 1.5 h / 20 °C 2: 90 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Guerrera; Salerno; Sarva; Siracusa; Lamartina; Caruso; Cutuli
Farmaco, 1992 , vol. 47, # 9 p. 1149 - 1160
反应条件
1: 22 percent / 90percent aq. nitric acid / acetic acid; acetic anhydride / 1.5 h / 20 °C 2: 90 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Guerrera; Salerno; Sarva; Siracusa; Lamartina; Caruso; Cutuli
Farmaco, 1992 , vol. 47, # 9 p. 1149 - 1160
反应条件
1: 22 percent / 90percent aq. nitric acid / acetic acid; acetic anhydride / 1.5 h / 20 °C 2: 90 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Guerrera; Salerno; Sarva; Siracusa; Lamartina; Caruso; Cutuli
Farmaco, 1992 , vol. 47, # 9 p. 1149 - 1160
反应条件
1: 22 percent / 90percent aq. nitric acid / acetic acid; acetic anhydride / 1.5 h / 20 °C 2: 90 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Guerrera; Salerno; Sarva; Siracusa; Lamartina; Caruso; Cutuli
Farmaco, 1992 , vol. 47, # 9 p. 1149 - 1160
反应条件
1: 22 percent / 90percent aq. nitric acid / acetic acid; acetic anhydride / 1.5 h / 20 °C 2: 90 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Guerrera; Salerno; Sarva; Siracusa; Lamartina; Caruso; Cutuli
Farmaco, 1992 , vol. 47, # 9 p. 1149 - 1160
反应条件
1: 22 percent / 90percent aq. nitric acid / acetic acid; acetic anhydride / 1.5 h / 20 °C 2: 90 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Guerrera; Salerno; Sarva; Siracusa; Lamartina; Caruso; Cutuli
Farmaco, 1992 , vol. 47, # 9 p. 1149 - 1160
