2-氨基噻唑-5-羧酸乙酯合成路线 （共 23 条）
反应条件
1: With N-iodo-succinimide in acetonitrile T=20 - 90°C; Reflux; 2: With sodium hydroxide in water
参考文献
ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; HILPERT, Kurt; HUBLER, Francis; LEHMANN, David; MEYER, Emmanuel; RENNEBERG, Dorte
Patent: WO2010/122504 A1, 2010 ;
Location in patent: Page/Page column 53-54 ;
WO 2010/122504 A1
反应条件
in toluene
1 h; Heating;
参考文献
Rachlin, Schneur; Bramm, E.; Ahnfelt-Ronne, I.; Arrigoni-Martelli, E.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 13 - 20
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=0 - 20°C; 2 h;
参考文献
Shipps Jr., Gerald W.; Deng, Yongqi; Wang, Tong; Popovici-Muller, Janeta; Curran, Patrick J.; Rosner, Kristin E.; Cooper, Alan B.; Girijavallabhan, Viyyoor; Butkiewicz, Nancy; Cable, Michael
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 115 - 119
