2,3,4,6-四氟苯甲酸合成路线 （共 13 条）
反应条件
ruthenium trichloride; sodium periodate; water in tetrachloromethane; acetonitrile T=20°C; 6 h;
参考文献
PFIZER LIMITED
Patent: US2012/10207 A1, 2012 ;
Location in patent: Page/Page column 43 ;
US 20120010207 A1
反应条件
1: 1,2,3,5-Tetrafluorobenzene With n-butyllithium in tetrahydrofuran T=-70°C; Metallation; 2: carbon dioxide in tetrahydrofuran Carboxylation;
参考文献
Konovalov, Valery V.; Laev, Sergey S.; Beregovaya, Irina V.; Shchegoleva, Lyudmila N.; Shteingarts, Vitalij D.; Tsvetkov, Yuri D.; Bilkis, Itzhak
Journal of Physical Chemistry A, 2000 , vol. 104, # 2 p. 352 - 361
反应条件
in 1,4-dioxane; dimethyl sulfoxide a) 140 deg C, 4 h, b) 150 deg 30 min; Yield given;
参考文献
Fujita; Egawa; Kataoka; Miyamoto; Nakano; Matsumoto
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 12 p. 2123 - 2132
反应条件
ammonia; sodium T=-45°C; Reduction; Hydrodefluorination; 0.25 h; Title compound not separated from byproducts;
参考文献
Konovalov, Valery V.; Laev, Sergey S.; Beregovaya, Irina V.; Shchegoleva, Lyudmila N.; Shteingarts, Vitalij D.; Tsvetkov, Yuri D.; Bilkis, Itzhak
Journal of Physical Chemistry A, 2000 , vol. 104, # 2 p. 352 - 361
反应条件
1: 9 percent Spectr. / Zn; NH3 / -45 °C 2: 9 percent Spectr. / Na; NH3 / 0.25 h / -45 °C View Scheme
参考文献
Konovalov, Valery V.; Laev, Sergey S.; Beregovaya, Irina V.; Shchegoleva, Lyudmila N.; Shteingarts, Vitalij D.; Tsvetkov, Yuri D.; Bilkis, Itzhak
Journal of Physical Chemistry A, 2000 , vol. 104, # 2 p. 352 - 361
反应条件
ammonia; zinc T=-45°C; Reduction; Hydrodefluorination; Title compound not separated from byproducts;
参考文献
Konovalov, Valery V.; Laev, Sergey S.; Beregovaya, Irina V.; Shchegoleva, Lyudmila N.; Shteingarts, Vitalij D.; Tsvetkov, Yuri D.; Bilkis, Itzhak
Journal of Physical Chemistry A, 2000 , vol. 104, # 2 p. 352 - 361
反应条件
ammonia; zinc T=-45°C; Reduction; Hydrodefluorination; Title compound not separated from byproducts;
参考文献
Journal of Physical Chemistry A, , vol. 104, # 2 p. 352 - 361
反应条件
ammonia; sodium T=-45°C; Reduction; Hydrodefluorination; 0.25 h; Title compound not separated from byproducts;
参考文献
Journal of Physical Chemistry A, , vol. 104, # 2 p. 352 - 361
反应条件
in diethyl ether; water
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US6333431 B1, 2001 ;
反应条件
1: 9 percent Spectr. / Zn; NH3 / -45 °C 2: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C View Scheme
参考文献
Konovalov, Valery V.; Laev, Sergey S.; Beregovaya, Irina V.; Shchegoleva, Lyudmila N.; Shteingarts, Vitalij D.; Tsvetkov, Yuri D.; Bilkis, Itzhak
Journal of Physical Chemistry A, 2000 , vol. 104, # 2 p. 352 - 361
